Duan Lian, Xiong Xingjiang, Hu Junyuan, Liu Yongmei, Li Jun, Wang Jie
Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Science, Beijing, China.
Graduate School, Beijing University of Traditional Chinese Medicine, Beijing, China.
Front Pharmacol. 2017 Oct 17;8:702. doi: 10.3389/fphar.2017.00702. eCollection 2017.
Coronary artery disease (CAD) is a major public health problem and the chief cause of morbidity and mortality worldwide. , a valuable herb in traditional Chinese medicine (TCM) with obvious efficacy and favorable safety, shows a great promise as a novel option for CAD and is increasingly recognized clinically. Firstly, this review introduced recent clinical trials on treatment with PNS either alone or in combination with conventional drugs as novel treatment strategies. Then we discussed the mechanisms of and saponins (PNS), which can regulate signaling pathways associated with inflammation, lipid metabolism, the coagulation system, apoptosis, angiogenesis, atherosclerosis, and myocardial ischaemia.
冠状动脉疾病（CAD）是一个重大的公共卫生问题，也是全球发病和死亡的主要原因。三七，一种在传统中医（TCM）中具有显著疗效和良好安全性的珍贵草药，作为CAD的一种新选择显示出巨大的前景，并在临床上越来越受到认可。首先，本综述介绍了近期关于单独使用三七总皂苷（PNS）或与传统药物联合使用作为新治疗策略的临床试验。然后我们讨论了三七及三七总皂苷（PNS）的作用机制，其可调节与炎症、脂质代谢、凝血系统、细胞凋亡、血管生成、动脉粥样硬化和心肌缺血相关的信号通路。
