Araújo Elsa, Barbosa Manuel, Costa Raquel, Sousa Bárbara, Costa Vítor
Internal Medicine Department, Unidade Local de Saúde do Alto Minho, Ponte de Lima, Portugal.
Eur J Case Rep Intern Med. 2020 Jan 8;7(1):001356. doi: 10.12890/2020_001356. eCollection 2020.
Cutaneous metastasis has a frequency of 1 to 10% among all metastatic cancer forms and breast cancer accounts for 30% of all cases. We report the case of a 73-year-old woman who presented with 4 skin lesions distributed across the upper trunk and abdomen; these had developed over a period of 12 months. Over the previous 6 months she had also developed anorexia, asthenia and weight loss. Upon investigation, a nodular mass was found in the left breast. Skin and breast mass biopsy were performed. Histology confirmed the diagnosis: infiltrating lobular breast cancer with cutaneous metastasis. The patient underwent hormonal treatment, mastectomy and radiotherapy. In rare cases, cutaneous metastasis appears as the first clinical manifestation of breast cancer. It is therefore crucial for patients and health professionals alike to be aware of new skin lesions. Cutaneous metastasis is a diagnostic sign of cancer that, it must be emphasised, is not restricted exclusively to later forms of the disease.
Although breast cancer has the highest cutaneous metastasis rate among internal malignancies, cutaneous metastases actually occur in only a small minority of breast cancer patients. In rare cases, skin metastasis may appear as the first clinical manifestation of breast cancer.The clinical presentation of cutaneous metastasis from breast cancer can be varied, and therefore warrants greater awareness in clinical practice.Cutaneous metastasis from breast cancer typically carries a less unfavourable prognosis than cutaneous metastasis from other internal malignancies.
皮肤转移在所有转移性癌症类型中的发生率为1%至10%,其中乳腺癌占所有病例的30%。我们报告一例73岁女性患者,其躯干上部和腹部出现4处皮肤病变,这些病变在12个月内逐渐形成。在之前的6个月里,她还出现了厌食、乏力和体重减轻的症状。经检查,在左侧乳房发现一个结节状肿块。进行了皮肤和乳房肿块活检。组织学检查确诊为:浸润性小叶乳腺癌伴皮肤转移。患者接受了激素治疗、乳房切除术和放疗。在罕见情况下,皮肤转移表现为乳腺癌的首发临床表现。因此,患者和医护人员都必须对新出现的皮肤病变予以关注。皮肤转移是癌症的一个诊断标志,必须强调的是,它并非仅局限于疾病的晚期形式。
尽管乳腺癌在内部恶性肿瘤中皮肤转移率最高,但实际上只有一小部分乳腺癌患者会发生皮肤转移。在罕见情况下,皮肤转移可能表现为乳腺癌的首发临床表现。乳腺癌皮肤转移的临床表现可能多种多样,因此在临床实践中需要提高认识。与其他内部恶性肿瘤的皮肤转移相比,乳腺癌的皮肤转移通常预后较好。