The Transcriptome of Hepatic Fibrosis Revealed by Single-Cell RNA Sequencing.
作者信息
Jophlin Loretta L, Cao Sheng, Shah Vijay H
机构信息
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
出版信息
Hepatology. 2020 May;71(5):1865-1867. doi: 10.1002/hep.31155.
Abstract
摘要
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本文引用的文献
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Cell Rep. 2019 Nov 12;29(7):1832-1847.e8. doi: 10.1016/j.celrep.2019.10.024.
2
Resolving the fibrotic niche of human liver cirrhosis at single-cell level.解析人肝硬化的纤维性龛位于单细胞水平。
Nature. 2019 Nov;575(7783):512-518. doi: 10.1038/s41586-019-1631-3. Epub 2019 Oct 9.
3
Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis.单细胞分泌组基因分析揭示健康和 NASH 肝脏中的细胞间串扰景观。
Mol Cell. 2019 Aug 8;75(3):644-660.e5. doi: 10.1016/j.molcel.2019.07.028.
4
A human liver cell atlas reveals heterogeneity and epithelial progenitors.人类肝脏细胞图谱揭示了其异质性和上皮祖细胞。
Nature. 2019 Aug;572(7768):199-204. doi: 10.1038/s41586-019-1373-2. Epub 2019 Jul 10.
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Integrative single-cell analysis.整合单细胞分析。
Nat Rev Genet. 2019 May;20(5):257-272. doi: 10.1038/s41576-019-0093-7.
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Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris.单细胞转录组学分析 20 种小鼠器官构建小鼠多器官单细胞图谱。
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