• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
The Transcriptome of Hepatic Fibrosis Revealed by Single-Cell RNA Sequencing.单细胞RNA测序揭示的肝纤维化转录组
Hepatology. 2020 May;71(5):1865-1867. doi: 10.1002/hep.31155.
2
Key Anti-Fibrosis Associated Long Noncoding RNAs Identified in Human Hepatic Stellate Cell via Transcriptome Sequencing Analysis.通过转录组测序分析鉴定人肝星状细胞中关键的抗纤维化相关长非编码 RNA。
Int J Mol Sci. 2018 Feb 27;19(3):675. doi: 10.3390/ijms19030675.
3
Transcriptome Analysis of Porcine PBMCs Reveals the Immune Cascade Response and Gene Ontology Terms Related to Cell Death and Fibrosis in the Progression of Liver Failure.猪 PBMCs 转录组分析揭示了肝衰竭进展中与细胞死亡和纤维化相关的免疫级联反应和基因本体论术语。
Can J Gastroenterol Hepatol. 2018 Apr 12;2018:2101906. doi: 10.1155/2018/2101906. eCollection 2018.
4
Altered AKAP12 expression in portal fibroblasts and liver sinusoids mediates transition from hepatic fibrogenesis to fibrosis resolution.门脉成纤维细胞和肝窦中 AKAP12 表达的改变介导了肝纤维化向纤维化消退的转变。
Exp Mol Med. 2018 Apr 27;50(4):1-13. doi: 10.1038/s12276-018-0074-5.
5
Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblasts in Liver Fibrosis.单细胞 RNA 测序鉴定肝纤维化中肝星状细胞和肌成纤维细胞亚群。
Cells. 2019 May 24;8(5):503. doi: 10.3390/cells8050503.
6
Transcriptomic analyses reveal the molecular mechanisms of schisandrin B alleviates CCl-induced liver fibrosis in rats by RNA-sequencing.转录组分析通过 RNA 测序揭示五味子乙素通过减轻 CCl 诱导的大鼠肝纤维化的分子机制。
Chem Biol Interact. 2019 Aug 25;309:108675. doi: 10.1016/j.cbi.2019.05.041. Epub 2019 May 28.
7
Analysis of disease-associated protein expression using quantitative proteomics—fibulin-5 is expressed in association with hepatic fibrosis.使用定量蛋白质组学分析疾病相关蛋白表达——纤连蛋白-5与肝纤维化相关表达。
J Proteome Res. 2015 May 1;14(5):2278-86. doi: 10.1021/acs.jproteome.5b00053. Epub 2015 Apr 6.
8
Thymosin-β4 Mediates Hepatic Stellate Cell Activation by Interfering with CircRNA-0067835/miR-155/FoxO3 Signaling Pathway.胸腺素-β4通过干扰CircRNA-0067835/miR-155/FoxO3信号通路介导肝星状细胞激活。
Cell Physiol Biochem. 2018;51(3):1389-1398. doi: 10.1159/000495556. Epub 2018 Nov 27.
9
High-throughput sequencing reveals altered expression of hepatic microRNAs in nonalcoholic fatty liver disease-related fibrosis.高通量测序揭示非酒精性脂肪性肝病相关纤维化中肝脏微小RNA的表达改变。
Transl Res. 2015 Sep;166(3):304-14. doi: 10.1016/j.trsl.2015.04.014. Epub 2015 May 4.
10
Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men.因子 VII 激活蛋白酶(FSAP)在小鼠和人类的肝纤维化中发挥抗炎和抗纤维化作用。
J Hepatol. 2013 Jan;58(1):104-11. doi: 10.1016/j.jhep.2012.09.007. Epub 2012 Sep 16.

引用本文的文献

1
Oxidative stress promotes liver fibrosis by modulating the microRNA-144 and SIN3A-p38 pathways in hepatic stellate cells.氧化应激通过调节肝星状细胞中的 microRNA-144 和 SIN3A-p38 通路促进肝纤维化。
Int J Biol Sci. 2024 Apr 8;20(7):2422-2439. doi: 10.7150/ijbs.92749. eCollection 2024.
2
Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis.牛磺酸通过抑制自噬和诱导铁死亡来减轻肝星状细胞的激活。
World J Gastroenterol. 2024 Apr 21;30(15):2143-2154. doi: 10.3748/wjg.v30.i15.2143.
3
Binding of berberine to PEBP1 synergizes with sorafenib to induce the ferroptosis of hepatic stellate cells.小檗碱与 PEBP1 结合协同索拉非尼诱导肝星状细胞发生铁死亡。
Amino Acids. 2023 Dec;55(12):1867-1878. doi: 10.1007/s00726-023-03345-7. Epub 2023 Oct 9.
4
Multiplexed Digital Spatial Protein Profiling Reveals Distinct Phenotypes of Mononuclear Phagocytes in Livers with Advanced Fibrosis.多重数字空间蛋白质分析揭示了晚期纤维化肝脏中单核吞噬细胞的不同表型。
Cells. 2022 Oct 26;11(21):3387. doi: 10.3390/cells11213387.
5
An Overview on Single-Cell Technology for Hepatocellular Carcinoma Diagnosis.单细胞技术在肝细胞癌诊断中的应用概述。
Int J Mol Sci. 2022 Jan 26;23(3):1402. doi: 10.3390/ijms23031402.
6
A Unique Immune-Related Gene Signature Represents Advanced Liver Fibrosis and Reveals Potential Therapeutic Targets.一种独特的免疫相关基因特征代表晚期肝纤维化并揭示潜在治疗靶点。
Biomedicines. 2022 Jan 16;10(1):180. doi: 10.3390/biomedicines10010180.
7
Regulation and functional roles of chemokines in liver diseases.趋化因子在肝脏疾病中的调控作用和功能。
Nat Rev Gastroenterol Hepatol. 2021 Sep;18(9):630-647. doi: 10.1038/s41575-021-00444-2. Epub 2021 May 11.

本文引用的文献

1
Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis.单细胞转录组学揭示肝纤维化过程中间质功能的分区。
Cell Rep. 2019 Nov 12;29(7):1832-1847.e8. doi: 10.1016/j.celrep.2019.10.024.
2
Resolving the fibrotic niche of human liver cirrhosis at single-cell level.解析人肝硬化的纤维性龛位于单细胞水平。
Nature. 2019 Nov;575(7783):512-518. doi: 10.1038/s41586-019-1631-3. Epub 2019 Oct 9.
3
Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis.单细胞分泌组基因分析揭示健康和 NASH 肝脏中的细胞间串扰景观。
Mol Cell. 2019 Aug 8;75(3):644-660.e5. doi: 10.1016/j.molcel.2019.07.028.
4
A human liver cell atlas reveals heterogeneity and epithelial progenitors.人类肝脏细胞图谱揭示了其异质性和上皮祖细胞。
Nature. 2019 Aug;572(7768):199-204. doi: 10.1038/s41586-019-1373-2. Epub 2019 Jul 10.
5
Integrative single-cell analysis.整合单细胞分析。
Nat Rev Genet. 2019 May;20(5):257-272. doi: 10.1038/s41576-019-0093-7.
6
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris.单细胞转录组学分析 20 种小鼠器官构建小鼠多器官单细胞图谱。
Nature. 2018 Oct;562(7727):367-372. doi: 10.1038/s41586-018-0590-4. Epub 2018 Oct 3.
7
Single-cell RNA sequencing technologies and bioinformatics pipelines.单细胞 RNA 测序技术和生物信息学分析流程。
Exp Mol Med. 2018 Aug 7;50(8):1-14. doi: 10.1038/s12276-018-0071-8.
8
Extracellular matrix as a driver of progressive fibrosis.细胞外基质作为进行性纤维化的驱动因素。
J Clin Invest. 2018 Jan 2;128(1):45-53. doi: 10.1172/JCI93557.

The Transcriptome of Hepatic Fibrosis Revealed by Single-Cell RNA Sequencing.

作者信息

Jophlin Loretta L, Cao Sheng, Shah Vijay H

机构信息

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.

出版信息

Hepatology. 2020 May;71(5):1865-1867. doi: 10.1002/hep.31155.

DOI:10.1002/hep.31155
PMID:32017148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7192776/
Abstract
摘要