Institute of Biomedical Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, China.
Thorac Cancer. 2020 Mar;11(3):519-525. doi: 10.1111/1759-7714.13344. Epub 2020 Feb 4.
Cell junctions serve as a protective barrier for cells and provide an important channel for information transmission between cells and the surrounding environment. Viruses are parasites that invade and commandeer components of host cells in order to survive and replicate, and they have evolved various mechanisms to alter cell junctions to facilitate viral infection. In this review, we examined the current state of knowledge on the action of viruses on host cell junctions. The existing evidence suggests that targeting the molecules involved in the virus-cell junction interaction can prevent the spread of viral diseases.
细胞连接作为细胞的保护屏障,为细胞与周围环境之间的信息传递提供了重要通道。病毒是一种寄生虫,为了生存和复制,它们会入侵和利用宿主细胞的成分,并进化出各种机制来改变细胞连接,以促进病毒感染。在这篇综述中,我们研究了病毒对宿主细胞连接作用的现有知识状态。现有证据表明,靶向病毒-细胞连接相互作用中涉及的分子可以阻止病毒疾病的传播。