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细菌、病毒和真菌感染相关的帕金森病风险：队列研究和病例对照研究的荟萃分析。

Bacterial, viral, and fungal infection-related risk of Parkinson's disease: Meta-analysis of cohort and case-control studies.

机构信息

Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

出版信息

Brain Behav. 2020 Mar;10(3):e01549. doi: 10.1002/brb3.1549. Epub 2020 Feb 4.

DOI:10.1002/brb3.1549
PMID:32017453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7066372/
Abstract

AIMS

Recent studies showed that patients with various bacterial, viral, and fungal infections might be at increased risk of Parkinson's disease (PD). However, the risk of PD in patients with each specific infection varied. This meta-analysis estimated the association between various infections and PD risk.

METHODS

Literature published from January 1965 to October 2019 in PubMed and EMBASE databases was searched. Data were extracted and pooled using random/fixed effects model. Sensitivity analysis and meta-regression were also performed to analyze the source of heterogeneity. Publication bias was estimated by the trim and fill.

RESULTS

Twenty-three out of 6,609 studies were included. Helicobacter pylori (HP; pooled OR = 1.653, 1.426-1.915, p < .001), hepatitis C virus (HCV; pooled OR = 1.195, 1.012-1.410, p = .035), Malassezia (pooled OR = 1.694, 1.367-2.100, p < .001), and pneumoniae (pooled OR = 1.595, 1.020-2.493, p = .041) infection were associated with increased PD risk. Influenza virus, herpes virus, hepatitis B virus, scarlet fever, mumps virus, chicken pox, pertussis, German measles, and measles were not associated with PD risk. After antiviral treatment against HCV reduced the risk of PD in patients with HCV infection (OR = 0.672, 0.571-0.791, p < .001). Significant heterogeneity exists among the included studies.

CONCLUSION

Patients with infection of HP, HCV, Malassezia, pneumoniae might be an increased risk of PD. Antiviral treatment of HCV could reduce the risk of PD.

摘要

目的

最近的研究表明，患有各种细菌、病毒和真菌感染的患者患帕金森病（PD）的风险可能会增加。然而，每种特定感染的 PD 风险各不相同。本荟萃分析评估了各种感染与 PD 风险之间的关联。

方法

检索了 1965 年 1 月至 2019 年 10 月期间在 PubMed 和 EMBASE 数据库中发表的文献。使用随机/固定效应模型提取和汇总数据。还进行了敏感性分析和荟萃回归分析，以分析异质性的来源。通过修剪和填充法估计发表偏倚。

结果

23 项研究符合纳入标准，共纳入 6609 项研究。幽门螺杆菌（HP；汇总 OR=1.653，1.426-1.915，p<0.001）、丙型肝炎病毒（HCV；汇总 OR=1.195，1.012-1.410，p=0.035）、马拉色菌（汇总 OR=1.694，1.367-2.100，p<0.001）和肺炎球菌（汇总 OR=1.595，1.020-2.493，p=0.041）感染与 PD 风险增加相关。流感病毒、疱疹病毒、乙型肝炎病毒、猩红热、腮腺炎病毒、水痘、百日咳、风疹和麻疹与 PD 风险无关。针对 HCV 的抗病毒治疗降低了 HCV 感染患者 PD 的风险（OR=0.672，0.571-0.791，p<0.001）。纳入的研究之间存在显著的异质性。

结论

感染 HP、HCV、马拉色菌和肺炎球菌的患者患 PD 的风险可能会增加。针对 HCV 的抗病毒治疗可能会降低 PD 的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66bd/7066372/152d3d601056/BRB3-10-e01549-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66bd/7066372/da4803c1e4e1/BRB3-10-e01549-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66bd/7066372/2f18c39a3aa5/BRB3-10-e01549-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66bd/7066372/34864dd209d9/BRB3-10-e01549-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66bd/7066372/434443f80495/BRB3-10-e01549-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66bd/7066372/6ea8d683f217/BRB3-10-e01549-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66bd/7066372/152d3d601056/BRB3-10-e01549-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66bd/7066372/da4803c1e4e1/BRB3-10-e01549-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66bd/7066372/4fb53d1198f5/BRB3-10-e01549-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66bd/7066372/2f18c39a3aa5/BRB3-10-e01549-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66bd/7066372/6ea8d683f217/BRB3-10-e01549-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66bd/7066372/152d3d601056/BRB3-10-e01549-g007.jpg

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