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痴呆症和帕金森病中人类白细胞抗原（HLA）的共同覆盖情况。

Shared Human Leukocyte Antigen (HLA) Coverage in dementia and Parkinson's disease.

作者信息

James Lisa M, Georgopoulos Apostolos P

机构信息

Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, MN, 55417, USA.

Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

出版信息

J Neurol Neuromedicine. 2020 Sep 22;5(3):45-54. doi: 10.29245/2572.942x/2020/3.1275.

DOI:10.29245/2572.942x/2020/3.1275
PMID:40371005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12077135/
Abstract

Dementia and Parkinson's disease are the two most common age-related neurodegenerative conditions. Recent studies have identified Human Leukocyte Antigen (HLA) Class II DRB1 alleles that are protective or neutral with respect to dementia. Here we extend those findings to evaluate the association of the population frequency of HLA DRB1 alleles with the prevalence of dementia and Parkinson's disease in14 Continental Western European countries. Nine HLA DRB1 alleles were identified including four that are protective against dementia (DRB101:01, DRB104:01, DRB113:02, DRB115:01), three that are neutral (DRB103:01, DRB107:01, DRB108:01), and two susceptibility alleles (DRB111:01, DRB1*04:05). Results demonstrated that the population prevalence's of dementia and Parkinson's disease are highly correlated and that the association between the nine DRB1 alleles above and the population prevalence of dementia is highly overlapping with that of Parkinson's disease. These findings suggest a common HLA Class II DRB1 profile. Given the diverse role of HLA Class II alleles in protection from foreign antigens, autoimmunity, and, possibly, neuroprotection, the shared HLA profile between dementia and Parkinson's disease indicates that common immunogenetic mechanisms underlie the pathogenesis and manifestation of these diseases.

摘要

痴呆症和帕金森病是两种最常见的与年龄相关的神经退行性疾病。最近的研究已经确定了人类白细胞抗原（HLA）II类DRB1等位基因，这些等位基因对痴呆症具有保护作用或呈中性。在此，我们扩展这些发现，以评估HLA DRB1等位基因的人群频率与14个西欧大陆国家痴呆症和帕金森病患病率之间的关联。我们确定了9个HLA DRB1等位基因，其中4个对痴呆症有保护作用（DRB101:01、DRB104:01、DRB113:02、DRB115:01），3个呈中性（DRB103:01、DRB107:01、DRB108:01），还有2个易感等位基因（DRB111:01、DRB1*04:05）。结果表明，痴呆症和帕金森病的人群患病率高度相关，并且上述9个DRB1等位基因与痴呆症人群患病率之间的关联与帕金森病的关联高度重叠。这些发现表明存在一种共同的HLA II类DRB1特征。鉴于HLA II类等位基因在抵御外来抗原、自身免疫以及可能的神经保护方面具有多种作用，痴呆症和帕金森病之间共享的HLA特征表明，这些疾病的发病机制和表现有共同的免疫遗传机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/0040cd646063/nihms-2079205-f0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/765e9866cee0/nihms-2079205-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/ce2eeb64cb1a/nihms-2079205-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/d4b886153248/nihms-2079205-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/532fa714354b/nihms-2079205-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/3edc5e814674/nihms-2079205-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/32788ac6983d/nihms-2079205-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/5f05cb5511e6/nihms-2079205-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/3857c2abe1aa/nihms-2079205-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/c536ef459096/nihms-2079205-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/8ee21d745392/nihms-2079205-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/e02837a9ad28/nihms-2079205-f0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/9a3986d013a2/nihms-2079205-f0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/85bce127e08f/nihms-2079205-f0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/0040cd646063/nihms-2079205-f0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/765e9866cee0/nihms-2079205-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/ce2eeb64cb1a/nihms-2079205-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/d4b886153248/nihms-2079205-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/532fa714354b/nihms-2079205-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/3edc5e814674/nihms-2079205-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/32788ac6983d/nihms-2079205-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/5f05cb5511e6/nihms-2079205-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/3857c2abe1aa/nihms-2079205-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/c536ef459096/nihms-2079205-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/8ee21d745392/nihms-2079205-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/e02837a9ad28/nihms-2079205-f0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/9a3986d013a2/nihms-2079205-f0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/85bce127e08f/nihms-2079205-f0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2beb/12077135/0040cd646063/nihms-2079205-f0014.jpg

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[2]
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[3]
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[4]
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[5]
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[6]
Association of Dementia Human Leukocyte Antigen (HLA) Profile with Human Herpes Viruses 3 and 7: An in silico Investigation.

J Immunol Sci. 2021

[7]
Immunogenetic Epidemiology of Dementia and Parkinson's Disease in 14 Continental European Countries: Shared Human Leukocyte Antigen (HLA) Profiles.

J Immunol Sci. 2021-4-28

本文引用的文献

[1]
The Human Leukocyte Antigen (HLA) DRB1*13:02 Allele Protects against Dementia in Continental Western Europe.

J Neurol Neuromedicine. 2019-9-9

[2]
Persistent Antigens Hypothesis: The Human Leukocyte Antigen (HLA) Connection.

J Neurol Neuromedicine. 2018-12-24

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In silico assessment of binding affinities of three dementia-protective Human Leukocyte Antigen (HLA) alleles to nine human herpes virus antigens.

Curr Res Transl Med. 2020-11

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genotype regulates pathology and disease progression in synucleinopathy.

Sci Transl Med. 2020-2-5

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