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4
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MS 衍生同位素精细结构揭示福拉林 A 是一种含硫酮的海洋来源天然产物。

MS-Derived Isotopic Fine Structure Reveals Forazoline A as a Thioketone-Containing Marine-Derived Natural Product.

机构信息

Pharmaceutical Sciences Division , University of Wisconsin-Madison , Madison , Wisconsin 53705 , United States.

Merck & Co., Inc. , 320 Bent Street , Cambridge , Massachusetts 02141 , United States.

出版信息

Org Lett. 2020 Feb 21;22(4):1275-1279. doi: 10.1021/acs.orglett.9b04535. Epub 2020 Feb 4.

DOI:10.1021/acs.orglett.9b04535
PMID:32017574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7494057/
Abstract

Forazoline A is a structurally complex PKS-NRPS hybrid produced by marine-derived sp. During the course of studies highlighting the application of IFS analysis as a powerful tool for natural products analysis, we were alerted to an earlier misinterpretation with respect to forazoline A structure elucidation. In particular, IFS reveals that forazoline A contains a thioketone moiety rarely seen in secondary metabolites and, thus, constitutes an even more intriguing structure than originally thought.

摘要

Forazoline A 是一种结构复杂的 PKS-NRPS 杂合产物，由海洋来源的 sp. 产生。在强调 IFS 分析作为天然产物分析有力工具的应用研究过程中，我们注意到以前对 forazoline A 结构解析的一个误解。特别是，IFS 揭示了 forazoline A 含有一个硫酮部分，这在次级代谢产物中很少见，因此，它的结构比最初认为的更加有趣。