Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
J Nat Prod. 2021 Jan 22;84(1):136-141. doi: 10.1021/acs.jnatprod.0c01170. Epub 2020 Dec 18.
Chemical investigation of a marine sponge-associated sp. led to the discovery of bacillibactins E and F ( and ). Despite containing the well-established cyclic triester core of iron-binding natural products such as enterobactin, bacillibactins E and F ( and ) are the first bacterial siderophores that contain nicotinic and benzoic acid moieties. The structures of the new compounds, including their absolute configurations, were determined by extensive spectroscopic analyses and Marfey's method. A plausible biosynthetic pathway to and is proposed; this route bears great similarity to other previously established bacillibactin-like pathways but appears to differentiate itself by a promiscuous DhbE, which likely installs the nicotinic moiety of and the benzoic acid group of .
海洋海绵共生菌 sp 的化学研究发现了 bacillibactins E 和 F（和）。尽管 bacillibactins E 和 F（和）含有铁结合天然产物如 enterobactin 中常见的环三酯核心，但它们是第一个含有烟酸和苯甲酸部分的细菌铁载体。新化合物的结构，包括它们的绝对构型，通过广泛的光谱分析和 Marfey 的方法确定。提出了一个合理的生物合成途径到和；这条路线与其他以前建立的 bacillibactin 样途径非常相似，但似乎通过一个混杂的 DhbE 使其与众不同，该途径可能安装了烟酸部分和的苯甲酸基团。
