Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, Deemed to be University, Mumbai 400 056, India.
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, Deemed to be University, Mumbai 400 056, India.
Life Sci. 2020 Mar 15;245:117394. doi: 10.1016/j.lfs.2020.117394. Epub 2020 Feb 1.
Neurodegenerative diseases need the drugs to be delivered right inside the brain to maximizing the therapeutic effects. This can be achieved by use of novel targeted delivery systems such as nanoemulsions. Nanoemulsions (NE) are nano-sized emulsions that are manufactured for enhancing the delivery of drugs to the targeted site and minimize adverse effects and toxic reactions. Looking into the advanced pharmaceutical applications of NE, the present review gives an insight to the understanding of the application of NE in NDs like AD, PD and Prion's disease. The review also touches upon the pathophysiology of these ND diseases to have a clear understanding of the molecular aspects of the disease. Finally, the review sets a standpoint of nanoemulsion's significance in the treatment therapy of ND besides the drawbacks associated with the current drug therapy in NDs.
神经退行性疾病需要将药物直接递送到大脑内部，以最大限度地提高治疗效果。这可以通过使用新型靶向递药系统如纳米乳剂来实现。纳米乳剂（NE）是纳米级乳剂，用于增强药物递送到靶向部位，并最小化不良反应和毒性反应。本文着眼于 NE 在药物制剂中的应用，深入了解了 NE 在神经退行性疾病（如 AD、PD 和朊病毒病）中的应用。本文还涉及这些 ND 疾病的病理生理学，以便更清楚地了解疾病的分子方面。最后，本文除了讨论与 ND 目前药物治疗相关的缺点外，还从纳米乳剂在 ND 治疗中的意义方面进行了评价。
