The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
School of Traditional Chinese Medicine, Jinan University, Guangzhou 510630, China.
Diabetes Res Clin Pract. 2020 Apr;162:108044. doi: 10.1016/j.diabres.2020.108044. Epub 2020 Feb 1.
The objective of the present analysis was to evaluate and quantify the risk for gestational diabetes mellitus (GDM) according to maternal age.
Three electronic databases were searched for publications from inception to July 2018. Odds ratio (OR) and 95% confidence interval (95% CI) were calculated. A dose-response analsis was performed using generalised least squares regression. Subgroup and meta-regression analyses were conducted to explore the source of identified heterogeneity among studies.
Twenty-four studies were included in the present meta-analysis. The ORs and 95% CIs for women aged <20 years vs 25-29 years, 30-34 years, 35-39 years and ≥40 years were 0.60 (95% CI = 0.50-0.72), 1.69 (95% CI = 1.49-1.93), 2.73 (95% CI = 2.28-3.27), 3.54 (95% CI = 2.88-4.34) and 4.86 (95% CI = 3.78-6.24), respectively. Dose-response analysis showed that GDM risk exhibited a linear relationship with maternal age (P < 0.001). For each one-year increase in maternal age from 18 years, GDM risk for the overall population, Asian, and Europid increased by 7.90%, 12.74%, and 6.52%, respectively. Subgroup analyses indicated that from the age of 25, Asian women had a significantly higher risk of developing GDM than Europid women (all P < 0.001).
This meta-analysis demonstrates that the risk of GDM increases linearly with successive age-groups.
本分析旨在评估和量化孕妇年龄与妊娠期糖尿病（GDM）风险的关系。
检索了从创建到 2018 年 7 月的三个电子数据库，以评估 GDM 风险与母亲年龄之间的关系。计算比值比（OR）和 95%置信区间（95%CI）。采用广义最小二乘回归进行剂量反应分析。进行亚组和荟萃回归分析，以探索研究之间异质性的来源。
本荟萃分析共纳入 24 项研究。与 25-29 岁相比，<20 岁、30-34 岁、35-39 岁和≥40 岁的女性患 GDM 的 OR 和 95%CI 分别为 0.60（95%CI=0.50-0.72）、1.69（95%CI=1.49-1.93）、2.73（95%CI=2.28-3.27）、3.54（95%CI=2.88-4.34）和 4.86（95%CI=3.78-6.24）。剂量反应分析表明，GDM 风险与母亲年龄呈线性关系（P<0.001）。母亲年龄每增加 1 岁，总体人群、亚洲人群和欧洲人群的 GDM 风险分别增加 7.90%、12.74%和 6.52%。亚组分析表明，从 25 岁开始，亚洲女性患 GDM 的风险明显高于欧洲女性（均 P<0.001）。
本荟萃分析表明，GDM 风险随年龄递增呈线性增加。
