Stiller D, Holzhausen H J, Meyer H
Institut für Pathologische Anatomie, Martin-Luther-Universität Halle - Wittenberg, DDR.
Zentralbl Allg Pathol. 1988;134(4-5):467-77.
Epithelioid sarcoma is a rare but distinctive soft tissue tumor showing characteristic histologic features associated with a typical course, but there is still some debate as to its histogenesis. Two cases of this unique tumor were analyzed using the electron microscope. Light microscopically the diagnostically relevant cell type is oval to polyhedral exhibiting a dense eosinophilic cytoplasm. In such epithelioid cells the cytoplasm may sometimes be completely filled with an inclusion-body like hyaline eosinophilic material. Ultrastructurally the most striking feature are abundant intermediate-type filaments in these eosinophilic cells. While none of the electron microscopic findings is specific, the accumulation of the intermediate-type filaments in conjunction with the other cellular features described in sufficiently consistent and distinctive and can thus be used for confirming the diagnosis. In formalin-fixed specimens the electron microscopical investigation may be helpful in everyday diagnosis. The suggestion from the literature that epithelioid sarcoma is related to the synovial sarcoma can not be supported by our ultrastructural findings.
上皮样肉瘤是一种罕见但独特的软组织肿瘤，具有与典型病程相关的特征性组织学特征，但其组织发生仍存在一些争议。使用电子显微镜分析了两例这种独特的肿瘤。光镜下，具有诊断意义的细胞类型为椭圆形至多面体形，细胞质嗜酸性致密。在这些上皮样细胞中，细胞质有时可能完全充满一种类似包涵体的嗜酸性透明物质。超微结构上，最显著的特征是这些嗜酸性细胞中有丰富的中间丝。虽然没有一项电镜检查结果具有特异性，但中间丝的聚集与所描述的其他细胞特征相结合，具有足够的一致性和独特性，因此可用于确诊。在福尔马林固定的标本中，电镜检查可能有助于日常诊断。文献中关于上皮样肉瘤与滑膜肉瘤相关的观点不能得到我们超微结构研究结果的支持。
