Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193, Republic of South Africa.
Department of Biosciences, Council for Scientific and Industrial Research, Meiring Naude Rd, Brummeria, Pretoria, South Africa.
Mol Biol Rep. 2020 Mar;47(3):2361-2369. doi: 10.1007/s11033-020-05269-x. Epub 2020 Feb 4.
Gallbladder cancer (GBC) has a poor prognosis with a 5-year survival rate suggesting the need for more effective treatment strategies. Studying the cross-talk of several pathways involved in crucial cellular and biological processes such as cell growth, proliferation, migration and apoptosis would prove beneficial in identifying key players of GBC progression and targeting them. This review highlights several pathways known to be dysregulated in GBC onset and progression and describes known and potential targets. Within these pathways, there are proteins involved in the signalling cascade, which may be targeted as potential biomarkers and drug targets. Furthermore, the cross-talk of these pathways is investigated in the context of GBC and the implications thereof. A better understanding of the pathways involved in GBC pathogenesis will aid clinicians in the prognosis, diagnosis and treatment of patients. There are significant clinical implications of GBC pathway-based studies as they permit the understanding of onset and progression of the disease.
胆囊癌（GBC）预后较差，5 年生存率表明需要更有效的治疗策略。研究涉及细胞生长、增殖、迁移和凋亡等关键细胞和生物学过程的几种途径的相互作用，将有助于确定 GBC 进展的关键参与者并针对这些参与者进行靶向治疗。本综述强调了几种在 GBC 发生和进展中失调的途径，并描述了已知和潜在的靶点。在这些途径中，有参与信号级联的蛋白质，它们可能作为潜在的生物标志物和药物靶点。此外，还研究了这些途径在 GBC 中的相互作用及其影响。更好地了解参与 GBC 发病机制的途径将有助于临床医生对患者进行预后、诊断和治疗。基于 GBC 途径的研究具有重要的临床意义，因为它们允许人们了解疾病的发生和进展。
