Narapareddy Laren, Wildman Derek E, Armstrong Don L, Weckle Amy, Bell Aleeca F, Patil Crystal L, Tardif Suzette D, Ross Corinna N, Rutherford Julienne N
Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia.
Genomics Program, College of Public Health, University of South Florida, Tampa, Florida.
Am J Primatol. 2020 Mar;82(3):e23101. doi: 10.1002/ajp.23101. Epub 2020 Feb 5.
Accumulating evidence suggests that dysregulation of placental DNA methylation (DNAm) is a mechanism linking maternal weight during pregnancy to metabolic programming outcomes. The common marmoset, Callithrix jaccus, is a platyrrhine primate species that has provided much insight into studies of the primate placenta, maternal condition, and metabolic programming, yet the relationships between maternal weight and placental DNAm are unknown. Here, we report genome-wide DNAm from term marmoset placentas using reduced representation bisulfite sequencing. We identified 74 genes whose DNAm pattern is associated with maternal weight during gestation. These genes are predominantly involved in energy metabolism and homeostasis, including the regulation of glycolytic and lipid metabolic processes pathways.
越来越多的证据表明，胎盘DNA甲基化（DNAm）失调是一种将孕期母体体重与代谢编程结果联系起来的机制。普通狨猴（Callithrix jaccus）是一种阔鼻猴灵长类动物，为灵长类胎盘、母体状况和代谢编程的研究提供了很多见解，但母体体重与胎盘DNAm之间的关系尚不清楚。在这里，我们使用简化代表性亚硫酸氢盐测序报告了足月狨猴胎盘的全基因组DNAm。我们鉴定出74个基因，其DNAm模式与孕期母体体重相关。这些基因主要参与能量代谢和体内平衡，包括糖酵解和脂质代谢过程途径的调节。
