Riesche Laren, Tardif Suzette D, Ross Corinna N, deMartelly Victoria A, Ziegler Toni, Rutherford Julienne N
University of Pennsylvania , Philadelphia, Pennsylvania.
Southwest National Primate Research Center , San Antonio, Texas.
Am J Physiol Regul Integr Comp Physiol. 2018 May 1;314(5):R684-R692. doi: 10.1152/ajpregu.00164.2017. Epub 2018 Feb 7.
Animal models have been critical in building evidence that the prenatal experience and intrauterine environment are capable of exerting profound and permanent effects on metabolic health through developmental programming of obesity. However, despite physiological and evolutionary similarities, nonhuman primate models are relatively rare. The common marmoset monkey ( Callithrix jacchus) is a New World monkey that has been used as a biomedical model for well more than 50 years and has recently been framed as an appropriate model for exploring early-life impacts on later health and disease. The spontaneous, multifactorial, and early-life development of obesity in the common marmoset make it a valuable research model for advancing our knowledge about the role of the prenatal and placental mechanisms involved in developmental programming of obesity. This paper provides a brief overview of obesity in the common marmoset, followed by a discussion of marmoset reproduction and placental characteristics. We then discuss the occurrence and utility of variable intrauterine environments in developmental programming in marmosets. Evidence of developmental programming of obesity will be given, and finally, we put forward future directions and innovations for including the placenta in developmental programming of obesity in the common marmoset.
产前经历和子宫内环境能够通过肥胖的发育编程对代谢健康产生深远且持久的影响。然而，尽管存在生理和进化上的相似性，但非人类灵长类动物模型相对较少。普通狨猴（Callithrix jacchus）是一种新大陆猴，作为生物医学模型已被使用了50多年，最近被视为探索早期生活对后期健康和疾病影响的合适模型。普通狨猴肥胖的自发、多因素及早期生活发展特征使其成为推进我们对肥胖发育编程中涉及的产前和胎盘机制作用认识的宝贵研究模型。本文简要概述了普通狨猴的肥胖情况，随后讨论了狨猴的繁殖和胎盘特征。接着，我们探讨了可变子宫内环境在狨猴发育编程中的发生情况和效用。将给出肥胖发育编程的证据，最后，我们提出了将胎盘纳入普通狨猴肥胖发育编程研究的未来方向和创新点。
