Zhou Lina, Ma Xiancang, Wang Wei
Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
Neuropsychiatr Dis Treat. 2020 Jan 9;16:81-86. doi: 10.2147/NDT.S216389. eCollection 2020.
The risk of coronary heart disease (CHD) in patients with major depressive disorder (MDD) is higher than that in the general population. However, the mechanisms underlying the increased CHD risk in patients with MDD remain unclear. Inflammation plays an important role in the pathogenesis of MDD and CHD. Therefore, we explored the relationship between inflammatory biomarkers and CHD risk in patients with MDD.
We included 454 patients with acute MDD and 458 controls that matched the sample in age and gender. A readily available complete blood count was used to reflect inflammation, and the risk of CHD was assessed using the Framingham risk score.
The results showed that patients with MDD showed low-grade inflammation with an elevated platelet (p<0.001) and monocyte count (p<0.001), high platelet/lymphocyte (p=0.003) and monocyte/lymphocyte ratios (p<0.001), and a raised systemic immune-inflammation index (p=0.002). In addition, monocyte count was the only factor significantly associated with CHD risk in patients with MDD (B=7.521, 95% CI: 3.409-11.633, t=3.594, p<0.001).
Collectively, the results of this study support the hypothesis that MDD is systemic inflammation, and suggest that monocyte count predicts the risk of CHD in patients with MDD.
重度抑郁症（MDD）患者患冠心病（CHD）的风险高于普通人群。然而，MDD患者CHD风险增加的潜在机制仍不清楚。炎症在MDD和CHD的发病机制中起重要作用。因此，我们探讨了炎症生物标志物与MDD患者CHD风险之间的关系。
我们纳入了454例急性MDD患者和458例年龄和性别相匹配的对照组。使用易于获得的全血细胞计数来反映炎症，并使用弗明汉风险评分评估CHD风险。
结果显示，MDD患者存在低度炎症，血小板（p<0.001）和单核细胞计数升高（p<0.001），血小板/淋巴细胞（p=0.003）和单核细胞/淋巴细胞比值升高（p<0.001），全身免疫炎症指数升高（p=0.002）。此外，单核细胞计数是与MDD患者CHD风险显著相关的唯一因素（B=7.521，95%CI：3.409-11.633，t=3.594，p<0.001）。
总体而言，本研究结果支持MDD是全身性炎症的假说，并表明单核细胞计数可预测MDD患者的CHD风险。
