Lee Da Young, Lim Jae Sung, Cho Kyung A
Department of Biochemistry, Chonnam National University Medical School, Hwasun, Korea.
Center for Creative Biomedical Scientists, Chonnam National University Medical School, Hwasun, Korea.
Chonnam Med J. 2020 Jan;56(1):12-19. doi: 10.4068/cmj.2020.56.1.12. Epub 2020 Jan 22.
The macrophage displays functional and phenotypic diversity, which appears, in no small part, to stem from the ability of macrophages to adapt functionally to changes in their tissue microenvironment. Here, we describe the differential activity of peritoneal macrophages with or without the presence of thioglycollate (TG), an inflammatory drug that encouraged the recruitment of macrophages, during aging. The peritoneal-resident macrophages dramatically reduced in phagocytosis and pro-inflammatory cytokines secretion with aging, whereas the functions of macrophages recruited by TG were not significantly changed with aging. These results suggest that macrophages may be changed by their environment in advanced age, and could provide possible explanations for the controversial results regarding differential changes in macrophages in other papers.
巨噬细胞表现出功能和表型的多样性，这在很大程度上似乎源于巨噬细胞在功能上适应其组织微环境变化的能力。在此，我们描述了在衰老过程中，存在或不存在巯基乙酸盐（TG）（一种促进巨噬细胞募集的炎性药物）时腹膜巨噬细胞的差异活性。随着衰老，腹膜驻留巨噬细胞的吞噬作用和促炎细胞因子分泌显著降低，而由TG募集的巨噬细胞的功能并未随衰老而发生显著变化。这些结果表明，巨噬细胞在高龄时可能会受到其环境的影响，这可能为其他论文中关于巨噬细胞差异变化的争议性结果提供解释。
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