CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.
J Mater Chem B. 2020 Apr 29;8(16):3408-3422. doi: 10.1039/c9tb02457c.
Analysis of circulating tumor cells (CTCs) can provide significant clinical information for tumors, which has proven to be helpful for cancer diagnosis, prognosis monitoring, treatment efficacy, and personalized therapy. However, CTCs are an extremely rare cell population, which challenges the isolation of CTCs from patient blood. Over the last few decades, many strategies for CTC detection have been developed based on the physical and biological properties of CTCs. Among them, nanostructured interfaces have been widely applied as CTC detection platforms to overcome the current limitations associated with CTC capture. Furthermore, aptamers have attracted significant attention in the detection of CTCs due to their advantages, including good affinity, low cost, easy modification, excellent stability, and low immunogenicity. In addition, effective and nondestructive release of CTCs can be achieved by aptamer-mediated methods that are used under mild conditions. Herein, we review some progress in the detection and release of CTCs through aptamer-functionalized nanostructured interfaces.
循环肿瘤细胞（CTCs）的分析可为肿瘤提供重要的临床信息，已被证明有助于癌症诊断、预后监测、治疗效果和个性化治疗。然而，CTCs 是一种极其罕见的细胞群体，这给从患者血液中分离 CTCs 带来了挑战。在过去的几十年中，已经基于 CTC 的物理和生物学特性开发了许多 CTC 检测策略。其中，纳米结构界面已被广泛用作 CTC 检测平台，以克服当前与 CTC 捕获相关的限制。此外，由于适配体具有亲和力好、成本低、易于修饰、稳定性好、免疫原性低等优点，在 CTC 的检测中引起了广泛关注。此外，适配体介导的方法可以在温和的条件下实现 CTC 的有效且非破坏性释放。在此，我们综述了通过适配体功能化纳米结构界面进行 CTC 检测和释放的一些进展。
