基于适配体的癌细胞分析与治疗。

Aptamer-Based Cancer Cell Analysis and Treatment.

机构信息

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, P. R. China.

Guangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, Guangxi, 541004, P. R. China.

出版信息

ChemistryOpen. 2022 Oct;11(10):e202200141. doi: 10.1002/open.202200141.

DOI:10.1002/open.202200141

PMID:36264016

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9583543/

Abstract

Aptamers are a class of single-stranded DNA or RNA oligonucleotides that can exclusively bind to various targets with high affinity and selectivity. Regarded as "chemical antibodies", aptamers possess several intrinsic advantages, including easy synthesis, convenient modification, high programmability, and good biocompatibility. In recent decades, many studies have demonstrated the superiority of aptamers as molecular tools for various biological applications, particularly in the area of cancer theranostics. In this review, we focus on recent progress in developing aptamer-based strategies for the precise analysis and treatment of cancer cells.

摘要

适配体是一类单链 DNA 或 RNA 寡核苷酸，能够专一地与各种靶标高亲和力和高选择性地结合。被称为“化学抗体”，适配体具有许多内在的优势，包括易于合成、方便修饰、高可编程性和良好的生物相容性。在最近几十年中，许多研究表明，适配体作为各种生物应用的分子工具具有优越性，特别是在癌症诊断和治疗领域。在这篇综述中，我们重点介绍了基于适配体的策略在精确分析和治疗癌细胞方面的最新进展。