海兔酰胺 A，一种来源于蓝细菌的高度甲基化线性九肽，以及建立 LCMS 分析 ，-二甲基缬氨酸的高灵敏度方法。
Heptavalinamide A, an Extensively -Methylated Linear Nonapeptide from a Cyanobacterium sp. and Development of a Highly Sensitive Analysis of ,-Dimethylvaline by LCMS.
机构信息
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences , The University of Tokyo , 1-1-1 Bunkyo-ku , Tokyo 113-8657 , Japan.
College of Bioresource Sciences , Nihon University , 1866 Kameino , Fujisawa , Kanagawa 252-0880 , Japan.
出版信息
Org Lett. 2020 Feb 21;22(4):1254-1258. doi: 10.1021/acs.orglett.9b04420. Epub 2020 Feb 5.
An extensively -methylated linear nonapeptide heptavalinamide A () was isolated from the marine cyanobacterium sp. collected at Kabira Reef of Ishigaki Island, Okinawa. The amino acid sequence of was assigned by interpretation of 2D NMR and MS/MS data. The absolute configurations of the constituent amino acids were determined by the application of Marfey's method. A method to assign the configuration of ,-dimethylvaline by LCMS is discussed.
从冲绳石垣岛的嘉比岛的卡比拉礁采集的海洋蓝细菌中分离到一个广泛甲基化的线性九肽 heptavalinamide A ()。通过二维 NMR 和 MS/MS 数据分析确定了 的氨基酸序列。应用 Marfey 法确定了组成氨基酸的绝对构型。讨论了通过 LCMS 对,-二甲基缬氨酸的构型进行赋值的方法。
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