Williams Philip G, Yoshida Wesley Y, Moore Richard E, Paul Valerie J
Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
J Nat Prod. 2003 Jul;66(7):1006-9. doi: 10.1021/np030114z.
A new cytotoxic peptide, which displayed an IC(50) value of 0.8 microM against KB cells, has been isolated from the marine cyanobacterium Symploca sp. The planar structure of tasiamide B (1), deduced by 2D NMR experiments, contains the unusual amino acid-derived residue 4-amino-3-hydroxy-5-phenylpentanoic acid (Ahppa). The configuration of 1 was deduced by HPLC analysis of degradation products.
从海洋蓝藻Symploca sp.中分离出一种新的细胞毒性肽，其对KB细胞的IC(50)值为0.8微摩尔。通过二维核磁共振实验推导得出的塔西酰胺B（1）的平面结构含有不寻常的氨基酸衍生残基4-氨基-3-羟基-5-苯基戊酸（Ahppa）。通过对降解产物的高效液相色谱分析推导得出1的构型。
