Szewczenko Janusz, Kajzer Wojciech, Kajzer Anita, Basiaga Marcin, Kaczmarek Marcin, Antonowicz Magdalena, Nowińska Katarzyna, Jaworska Joanna, Jelonek Katarzyna, Kasperczyk Janusz
Silesian University of Technology, Faculty of Biomedical Engineering, Department of Biomaterials and Medical Devices Engineering, Zabrze, Poland.
Faculty of Mining and Geology, Department of Applied Geology, Gliwice, Poland.
Acta Bioeng Biomech. 2019;21(4):83-92.
The aim of the study was to determine the influence of long term exposure to Ringer's solution of biodegradable polymer coatings containing an active substance on the Ti6Al7Nb alloy substrate on the physical and chemical properties of the coatings and the degradation process of the metal substrate. The studies used poly(L-lactide-co-trimethylene carbonate) P(L/TMC), poly(L-lactide-co-trimethylene carbonate-glycolide) P(L/TMC/G) and poly(D,L-lactide-glycolide) (PLGA) coatings applied to the anodically oxidized Ti6Al7Nb alloy by means of dipping method (1, 2 and 3 dips). The polymer coatings contained ciprofloxacin. Roughness and wettability tests were carried out on the substrate and polymer coatings, the pitting corrosion resistance of the substrate and samples with polymer coating was determined, the number of metallic ions released to the solution from the coated and uncoated samples was determined as well as the adhesion of polymer coatings. The research was supplemented by microscopic observations. The results of the research indicate different influence of exposure to Ringer's solution on the physical and chemical properties of biodegradable polymer coatings containing ciprofloxacin and the course of the degradation process of the metal substrate.
该研究的目的是确定长期暴露于含有活性物质的可生物降解聚合物涂层的林格氏溶液对Ti6Al7Nb合金基底上涂层的物理和化学性质以及金属基底降解过程的影响。研究使用了通过浸渍法（1次、2次和3次浸渍）施加到阳极氧化Ti6Al7Nb合金上的聚（L-丙交酯-共-三亚甲基碳酸酯）P（L/TMC）、聚（L-丙交酯-共-三亚甲基碳酸酯-乙交酯）P（L/TMC/G）和聚（D，L-丙交酯-乙交酯）（PLGA）涂层。聚合物涂层含有环丙沙星。对基底和聚合物涂层进行了粗糙度和润湿性测试，测定了基底和带有聚合物涂层的样品的耐点蚀性，测定了涂层和未涂层样品释放到溶液中的金属离子数量以及聚合物涂层的附着力。研究还辅以微观观察。研究结果表明，暴露于林格氏溶液对含有环丙沙星的可生物降解聚合物涂层的物理和化学性质以及金属基底降解过程的进程有不同影响。
