Gilcrease Gregory Winston, Padovan Dario, Heffler Enrico, Peano Cristiana, Massaglia Stefano, Roccatello Dario, Radin Massimo, Cuadrado Maria Josè, Sciascia Savino
UNESCO Chair, Department of Culture, Politics and Society, University of Turin, Italy.
Department of Agricultural, Forest and Food Sciences (DISAFA), University of Turin, Italy.
Eur J Rheumatol. 2020 Jan 1;7(1):31-34. doi: 10.5152/eurjrheum.2019.19141. Print 2020 Jan.
It has been documented that several major components of air pollution, including trace elements and polycyclic aromatic hydrocarbons, are associated with the prevalence of systemic lupus erythematosus (SLE). However, the impact of air pollution on the SLE disease activity is still elusive. In this paper, we review the current evidence investigating the link between air pollution, especially when measured as PM2.5, and SLE severity and activity.
A detailed literature search was applied a priori to the Ovid MEDLINE In-Process and Other Non-Indexed Citation 1986 to present. Presented abstracts from the European League Against Rheumatism and American College of Rheumatology (ACR)/Association for Rheumatology Health Professionals (ARHP) Annual Meetings (2011-2018) were also screened.
Out of a total of 1354 papers retrieved from search and references list for detailed evaluation, data from 652 patients with SLE from three studies were analyzed. Two studies had an observational longitudinal design, counting for 348 patients with a follow-up of 24 months and 79 months. Retrieved studies differed for disease activity assessment and air pollution quantifications.
Current evidence suggests that variations in air pollution may influence the disease activity in patients with SLE. However, the sample size, methodological biases, and differences across the studies make further research mandatory. Understanding the increased burden of SLE and its complications, not only from a medical, but also from a socio-demographic perspective, including an exposure to pollutants, should have implications for resource allocation and access to subspecialty care.
有文献记载，空气污染的几个主要成分，包括微量元素和多环芳烃，与系统性红斑狼疮（SLE）的患病率有关。然而，空气污染对SLE疾病活动的影响仍不明确。在本文中，我们综述了目前关于空气污染（尤其是以PM2.5衡量时）与SLE严重程度和活动之间联系的证据。
事先对1986年至今的Ovid MEDLINE在研及其他未索引引文进行了详细的文献检索。还筛选了欧洲抗风湿病联盟和美国风湿病学会（ACR）/风湿病健康专业人员协会（ARHP）年会（2011 - 2018年）的摘要。
从检索到的文献及参考文献列表中总共获取了1354篇论文进行详细评估，对三项研究中652例SLE患者的数据进行了分析。两项研究采用观察性纵向设计，涉及348例患者，随访时间分别为24个月和79个月。检索到的研究在疾病活动评估和空气污染量化方面存在差异。
目前的证据表明，空气污染的变化可能会影响SLE患者的疾病活动。然而，样本量、方法学偏差以及各研究之间的差异使得进一步研究成为必要。从医学以及社会人口学角度，包括接触污染物方面，了解SLE及其并发症不断增加的负担，应该会对资源分配和专科护理的可及性产生影响。
