Ruaro Barbara, Sulli Alberto, Casabella Andrea, Pizzorni Carmen, Paolino Sabrina, Smith Vanessa, Cutolo Maurizio
Unit of Pulmonology, University Hospital of Trieste,Trieste, Italy.
Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, San Martino Polyclinic Hospital, University of Genova, Genoa, Italy.
Eur J Rheumatol. 2021 Jan;8(1):7-11. doi: 10.5152/eurjrheum.2020.20027. Epub 2020 Nov 11.
This study aims to evaluate blood perfusion (BP) in various cutaneous regions of the hands and face in patients with systemic lupus erythematosus (SLE) and primary Raynaud's phenomenon (PRP) and healthy subjects (HS).
A total of 20 patients with SLE, 20 patients with PRP, and 20 HS were enrolled. BP was detected by laser speckle contrast analysis in different regions of the hand and at the facial level. The absolute nailfold capillary number (CN) was assessed by nailfold videocapillaroscopy.
Patients with SLE and PRP had significantly lower BP levels than those of HS in 3 hand areas (fingertip, palm, and periungual; p<0.01). However, the SLE, PRP, and HS groups had comparable BP values at the hand dorsum and face. The BP and CN values revealed a positive correlation in the periungual, fingertip, and palm of hands (p<0.01), only in patients with SLE.
Our data demonstrated a correlation between functional and morphological microvascular impairment in patients with SLE.
本研究旨在评估系统性红斑狼疮（SLE）患者、原发性雷诺现象（PRP）患者及健康受试者（HS）手部和面部各皮肤区域的血液灌注（BP）情况。
共纳入20例SLE患者、20例PRP患者和20名HS。通过激光散斑对比分析检测手部不同区域及面部的BP。通过甲襞视频毛细血管镜评估绝对甲襞毛细血管数量（CN）。
SLE患者和PRP患者在3个手部区域（指尖、手掌和甲周；p<0.01）的BP水平显著低于HS。然而，SLE组、PRP组和HS组在手背和面部的BP值相当。仅在SLE患者中，甲周、指尖和手掌部位的BP与CN值呈正相关（p<0.01）。
我们的数据表明SLE患者功能性和形态学微血管损伤之间存在相关性。
