性激素是否是导致癌症发病率性别差异的基础？在食管腺癌中检验直观性。
Do Sex Hormones Underlie Sex Differences in Cancer Incidence? Testing the Intuitive in Esophageal Adenocarcinoma.
机构信息
Slone Epidemiology Center, Boston University, Boston, Massachusetts, USA.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
出版信息
Am J Gastroenterol. 2020 Feb;115(2):211-213. doi: 10.14309/ajg.0000000000000511.
Abstract
Esophageal adenocarcinoma (EA) incidence is 4-8 times higher in men compared with women, yet this imbalance cannot be explained by known risk factors. This issue of The American Journal of Gastroenterology features results from only the second prospective study to assess whether prediagnostic sex steroid hormones underlie sex differences in EA. Xie et al. report that higher concentrations of testosterone and luteinizing hormone were associated with decreased EA risk. While contrary to the long-standing hypothesis that testosterone increases EA risk, these important results lay a foundation for additional studies to further elucidate this intuitive, intriguing, and evolving hypothesis.
摘要
食管腺癌（EA）的发病率男性是女性的 4-8 倍，但这一不平衡现象不能用已知的风险因素来解释。《美国胃肠病学杂志》的这一期特载了第二项旨在评估预测性激素是否是 EA 中性别差异的潜在基础的前瞻性研究的结果。谢等人报告说，较高的睾丸酮和黄体化激素浓度与 EA 风险降低相关。尽管与睾丸酮增加 EA 风险的长期假说相反，但这些重要的结果为进一步阐明这一直观、有趣且不断发展的假说的进一步研究奠定了基础。
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3
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5
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