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运用系统药理学方法探究生脉散治疗糖尿病心肌病的作用机制。

Use of a Systematic Pharmacological Methodology to Explore the Mechanism of Shengmai Powder in Treating Diabetic Cardiomyopathy.

机构信息

Department of Traditional Chinese Medicine, Shenzhen Luohu People's Hospital, Shenzhen, Guangdong, China (mainland).

Hunan University of Chinese Medicine, Changsha, Hunan, China (mainland).

出版信息

Med Sci Monit. 2020 Feb 5;26:e919029. doi: 10.12659/MSM.919029.

DOI:10.12659/MSM.919029
PMID:32023237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7020766/
Abstract

BACKGROUND Cardiovascular complications, such as diabetic cardiomyopathy (DCM), are the leading cause of death in diabetic patients. Shengmai Powder (SMP) was found to have cardioprotective effects. MATERIAL AND METHODS Based on the systematic pharmacological methodology, this research determined the genes of DCM and the known targets of SMP, predicted potential compounds and targets of SMP, constructed networks for DCM and SMP, and performed network analysis. RESULTS Five network were constructed: (1) the DCM gene PPI network; (2) the Compound-compound target network of SMP; (3) the SMP-DCM PPI network; (4) the Compound-known target network of SMP; (5) and the SMP known target-DCM PPI network. Several DCM and treatment related targets, clusters, signaling pathways, and biological processes were found. CONCLUSIONS SMP is able to regulate glycometabolism-related, lipid metabolism-related, inflammatory response-related, oxidative stress-related signaling pathways, and biological processes and targets, which suggests that SMP may have a therapeutic effect on DCM.

摘要

背景

心血管并发症，如糖尿病心肌病（DCM），是糖尿病患者死亡的主要原因。生脉散（SMP）具有心脏保护作用。

方法

基于系统药理学方法，本研究确定了 DCM 的基因和 SMP 的已知靶点，预测了 SMP 的潜在化合物和靶点，构建了 DCM 和 SMP 的网络，并进行了网络分析。

结果

构建了 5 个网络：（1）DCM 基因 PPI 网络；（2）SMP 的化合物-化合物靶点网络；（3）SMP-DCM PPI 网络；（4）SMP 已知靶点网络；（5）SMP 已知靶点-DCM PPI 网络。发现了几个与 DCM 和治疗相关的靶点、聚类、信号通路和生物学过程。

结论

SMP 能够调节糖代谢相关、脂代谢相关、炎症反应相关、氧化应激相关的信号通路和生物学过程及靶点，这表明 SMP 可能对 DCM 具有治疗作用。

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Cell Physiol Biochem. 2018;50(5):1726-1739. doi: 10.1159/000494791. Epub 2018 Nov 1.
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Ophiopogonin D Reduces Myocardial Ischemia-Reperfusion Injury via Upregulating CYP2J3/EETs in Rats.麦冬皂苷D通过上调大鼠CYP2J3/EETs减轻心肌缺血-再灌注损伤
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ShengMai-San Attenuates Cardiac Remodeling in Diabetic Rats by Inhibiting NOX-Mediated Oxidative Stress.生脉散通过抑制NOX介导的氧化应激减轻糖尿病大鼠的心脏重塑。
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Cell Physiol Biochem. 2018;49(4):1646-1658. doi: 10.1159/000493500. Epub 2018 Sep 18.
4
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