当非编码还不够时。

When non-coding is not enough.

机构信息

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX.

出版信息

J Exp Med. 2020 Mar 2;217(3). doi: 10.1084/jem.20192009.

DOI:10.1084/jem.20192009

PMID:32023341

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7062537/

Abstract

A new concept is emerging in the non-coding RNA (ncRNA) field: an increasing number of ncRNAs in fact codify for short peptides that have biological activities. In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20190950) report the identification of a long ncRNA (lncRNA)-encoded 60-amino acid polypeptide that they name ASRPS, as well as its ability to inhibit angiogenesis in the deadly triple-negative breast cancer (TNBC).

摘要

非编码 RNA（ncRNA）领域出现了一个新概念：越来越多的 ncRNA 实际上编码具有生物活性的短肽。在本期《实验医学杂志》（JEM）中，Wang 等人（https://doi.org/10.1084/jem.20190950）报道了一种长 ncRNA（lncRNA）编码的 60 个氨基酸多肽的鉴定，他们将其命名为 ASRPS，并发现它能够抑制致命的三阴性乳腺癌（TNBC）中的血管生成。