白细胞介素-17 在类风湿关节炎中的作用：探索与挑战。
Interleukin-17 in rheumatoid arthritis: Trials and tribulations.
机构信息
Centre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London, UK.
出版信息
J Exp Med. 2020 Mar 2;217(3). doi: 10.1084/jem.20192048.
Abstract
Interleukin-17A (IL-17A) is a pro-inflammatory cytokine with well-characterized biological effects on stromal cell activation, angiogenesis, and osteoclastogenesis. The presence of this cytokine in the inflamed joints of patients with rheumatoid arthritis (RA), together with compelling data from in vitro and experimental arthritis models demonstrating its pro-inflammatory effects, made this cytokine a strong candidate for therapeutic targeting. Clinical trials, however, have shown relatively modest success in RA as compared with other indications. Guided by recent insights in IL-17 biology, this review aims to explore possible reasons for the limited clinical efficacy of IL-17A blockade in RA, and what we can learn from these results going forward.
摘要
白细胞介素-17A（IL-17A）是一种促炎细胞因子，对基质细胞激活、血管生成和破骨细胞生成具有明确的生物学作用。这种细胞因子存在于类风湿关节炎（RA）患者的炎症关节中，并且来自体外和实验性关节炎模型的有力数据表明其具有促炎作用，这使得这种细胞因子成为治疗靶点的有力候选物。然而，与其他适应证相比，临床试验在 RA 中的相对成功率较低。本综述以 IL-17 生物学的最新见解为指导，旨在探讨 RA 中 IL-17A 阻断的临床疗效有限的可能原因，以及我们可以从这些结果中学到什么。
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