酒精造成其表观遗传标记。
Alcohol Makes Its Epigenetic Marks.
机构信息
Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA; Jesse Brown VA Medical Center, Chicago, IL 60612, USA.
Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA.
出版信息
Cell Metab. 2020 Feb 4;31(2):213-214. doi: 10.1016/j.cmet.2020.01.008.
Abstract
The toxic effects of alcohol consumption are dependent upon its metabolism in the liver to downstream metabolites: acetaldehyde, acetate, and acetyl-CoA. Recently, in Nature, Mews et al. (2019) have discovered that acetyl-CoA derived from alcohol plays an important epigenetic role in regulating ethanol's effects on the brain through histone acetylation.
摘要
酒精的毒性作用取决于其在肝脏中的代谢产物
乙醛、乙酸和乙酰辅酶 A。最近，在《自然》杂志上，Mews 等人（2019 年）发现，来自酒精的乙酰辅酶 A 通过组蛋白乙酰化在调节乙醇对大脑的作用方面发挥着重要的表观遗传作用。
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本文引用的文献
1
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Nature. 2019 Oct;574(7780):717-721. doi: 10.1038/s41586-019-1700-7. Epub 2019 Oct 23.
2
Global statistics on alcohol, tobacco and illicit drug use: 2017 status report.全球酒精、烟草和非法药物使用统计数据：2017 年现状报告。
Addiction. 2018 Oct;113(10):1905-1926. doi: 10.1111/add.14234. Epub 2018 Jun 4.
3
Alcohol effects on the epigenome in the germline: Role in the inheritance of alcohol-related pathology.酒精对生殖系表观基因组的影响：在酒精相关病理学遗传中的作用。
Alcohol. 2017 May;60:53-66. doi: 10.1016/j.alcohol.2016.12.007. Epub 2017 Mar 6.
4
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Neuropharmacology. 2017 Aug 1;122:74-84. doi: 10.1016/j.neuropharm.2017.02.002. Epub 2017 Feb 4.
5
Neurobiology of addiction: a neurocircuitry analysis.成瘾的神经生物学：神经回路分析
Lancet Psychiatry. 2016 Aug;3(8):760-773. doi: 10.1016/S2215-0366(16)00104-8.
6
Alcohol metabolism.酒精代谢。
Clin Liver Dis. 2012 Nov;16(4):667-85. doi: 10.1016/j.cld.2012.08.002.
7
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Int J Environ Res Public Health. 2010 Apr;7(4):1285-301. doi: 10.3390/ijerph7041285. Epub 2010 Mar 25.
8
HDAC2 negatively regulates memory formation and synaptic plasticity.组蛋白去乙酰化酶2负向调节记忆形成和突触可塑性。
Nature. 2009 May 7;459(7243):55-60. doi: 10.1038/nature07925.
9
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J Neurosci. 2008 Apr 2;28(14):3729-37. doi: 10.1523/JNEUROSCI.5731-07.2008.
10
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Alcohol Clin Exp Res. 2008 May;32(5):829-39. doi: 10.1111/j.1530-0277.2008.00630.x. Epub 2008 Mar 11.
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