Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, College of Health Sciences, WY 82071, USA.
Int J Environ Res Public Health. 2010 Apr;7(4):1285-301. doi: 10.3390/ijerph7041285. Epub 2010 Mar 25.
Alcohol abuse is a serious medical and social problem. Although light to moderate alcohol consumption is beneficial to cardiovascular health, heavy drinking often results in organ damage and social problems. In addition, genetic susceptibility to the effect of alcohol on cancer and coronary heart disease differs across the population. A number of mechanisms including direct the toxicity of ethanol, its metabolites [e.g., acetaldehyde and fatty acid ethyl esters (FAEEs)] and oxidative stress may mediate alcoholic complications. Acetaldehyde, the primary metabolic product of ethanol, is an important candidate toxin in developing alcoholic diseases. Meanwhile, free radicals produced during ethanol metabolism and FAEEs are also important triggers for alcoholic damages.
酗酒是一个严重的医学和社会问题。尽管轻度至中度饮酒有益于心血管健康，但酗酒常常导致器官损伤和社会问题。此外，人群对酒精致癌和冠心病的遗传易感性存在差异。一些机制包括乙醇的直接毒性、其代谢产物（如乙醛和脂肪酸乙酯（FAEE））和氧化应激，可能介导酒精性并发症。乙醛是乙醇的主要代谢产物，是导致酒精性疾病的重要候选毒素。同时，乙醇代谢过程中产生的自由基和 FAEE 也是酒精性损伤的重要触发因素。
