Zhonghua Gan Zang Bing Za Zhi. 2020 Jan 20;28(1):14-20. doi: 10.3760/cma.j.issn.1007-3418.2020.01.005.
Hepatocellular carcinoma (HCC) currently holds the second position for cause of cancer-related deaths in China. Most of the pathogenic characteristics of HCC in China follow the tri-step model of hepatitis B-cirrhosis-liver cancer. The screening of precancerous lesions of stomach cancer, colorectal cancer and cervical cancer has achieved remarkable results for the diagnosis and treatment of malignant tumors. Dysplastic nodules in the state of cirrhosis have strong potential for malignant changes, especially high-grade dysplastic nodules, have extremely high canceration rate. This expert consensus is based on the research results and clinical experience of foreign and native experts of this field. Furthermore, this consensus summarizes and defines high-grade dysplastic nodules of the liver as precancerous lesions of HCC through multidisciplinary collaboration in terms of conception, screening, diagnosis, treatment and follow-up, with the aim to reduce the HCC incidence and improve the overall therapeutic effect of HCC in China.
肝细胞癌（HCC）目前在中国癌症相关死亡原因中位居第二。中国HCC的大多数致病特征遵循乙肝-肝硬化-肝癌的三步模式。胃癌、结直肠癌和宫颈癌癌前病变的筛查在恶性肿瘤的诊断和治疗方面取得了显著成果。肝硬化状态下的发育异常结节具有很强的恶变潜能，尤其是高级别发育异常结节，癌变率极高。本专家共识基于该领域国内外专家的研究成果和临床经验。此外，本共识通过多学科协作，在概念、筛查、诊断、治疗及随访等方面，将肝脏高级别发育异常结节总结并定义为HCC的癌前病变，旨在降低中国HCC的发病率，提高HCC的整体治疗效果。
