Rojas-Núñez Irene, Moore Ashli F, Lorenzoni A Gino
Animal Science Department, The Pennsylvania State University, State College, PA 16802, USA.
Microorganisms. 2020 Feb 1;8(2):205. doi: 10.3390/microorganisms8020205.
Bacterial chondronecrosis with osteomyelitis (BCO) is a septic necrosis of the skeletal system of unknown origin and an important cause of lameness in broiler chickens. Epithelial inflammation has been proposed as an avenue for bacterial translocation leading to BCO. We evaluated the effect of subclinical necrotic enteritis (SNE), an intestinal inflammatory event, with the development of BCO. In each of two experiments, chickens were divided into three treatments: 1) SNE challenge, including both dietary (wheat- and fish-based diet) and intestinal pathogenic challenges ( and ), 2) dietary challenge only, and 3) control diet (corn- and soy-based diet). Floor ramps were introduced as part of an established method for increasing the frequency of BCO. The efficacy of the SNE challenge was corroborated by necropsy evaluation of a representative sample of the population. At the end of each experiment, all birds were evaluated for BCO. A high incidence of BCO was found, even in birds with no external signs of lameness. However, the incidence of BCO was not correlated with the intestinal challenge. Conclusions: under the conditions used in these studies, a treatment that is associated with severe damage to the intestinal mucosa does not change the incidence of BCO in broiler chickens.
细菌性软骨坏死伴骨髓炎（BCO）是一种病因不明的骨骼系统化脓性坏死，是肉鸡跛行的重要原因。上皮炎症被认为是导致BCO的细菌易位途径。我们评估了亚临床坏死性肠炎（SNE）这一肠道炎症事件对BCO发生发展的影响。在两项实验中，每组鸡均分为三种处理：1）SNE挑战组，包括饮食（基于小麦和鱼类的饲料）和肠道病原体挑战（ 和 ）；2）仅饮食挑战组；3）对照饲料组（基于玉米和大豆的饲料）。引入地面斜坡作为增加BCO发生率的既定方法的一部分。通过对群体代表性样本的尸检评估证实了SNE挑战的效果。在每个实验结束时，对所有鸡只进行BCO评估。即使在没有外部跛行迹象的鸡只中也发现了高发生率的BCO。然而，BCO的发生率与肠道挑战无关。结论：在这些研究中所采用的条件下，一种与肠道黏膜严重损伤相关的处理方式并不会改变肉鸡BCO的发生率。
