Departament of Dentistry, Faculty of Biologic Sciences and Health, Federal University of Jequitinhonha and Mucuri Valleys, Rua da Glória, 187, Centro, Diamantina, Minas Gerais, Brazil.
BMC Oral Health. 2020 Feb 5;20(1):41. doi: 10.1186/s12903-020-1029-5.
This study aimed to evaluate the efficacy of ozonized water on pain, oedema and trismus after impacted third molar mandibular surgeries when compared to double distilled water. A randomized triple blind trial was conducted.
Patients with third molars class II-B of Pell-Gregory were included, and surgical extraction was performed. Irrigation was done with ozonized (group 1) or double distilled water (group 2). The type of irrigation and the side to be operated were randomized. Neither the patients nor the operator or evaluator were aware of the irrigation solution. Pain, oedema and trismus were evaluated at baseline, 24-h, 48-h, 72-h and 7-days after treatment. The data were evaluated by Friedman, Wilcoxon, Mann-Whitney tests, and size effect.
It was included 8 men and 12 women, with a mean age of 20.9y.o. The initial pain mean was 7.94 (±12.81) (group 1) and 5.50 (±9.12) (group 2) (p > 0,05). There was a statistically significant reduction of pain, oedema and trismus in intragroup analysis (p < 0.05). There was no statistically significant difference (p > 0.05) when comparing the oedema and trismus between groups. The size effect ranged from small (0.23) to large (1.29).
It was concluded that ozonized water was compatible as irrigation method, not inferior to double distilled water, and had satisfactory effects on management of pain, oedema and trismus after surgical removal of the third molar.
This clinical trial was registered in ClinicalTrials.gov NCT03501225 on April 18, 2018.
本研究旨在评估与双蒸水相比，臭氧水在第三磨牙下颌阻生术后疼痛、肿胀和牙关紧闭方面的疗效。进行了一项随机三盲试验。
纳入 Pell-Gregory 分类为 II-B 的第三磨牙患者，并进行手术拔除。用臭氧水（第 1 组）或双蒸水（第 2 组）冲洗。冲洗类型和待手术侧均随机化。患者、操作者和评估者均不知道冲洗液的类型。在治疗后基线、24 小时、48 小时、72 小时和 7 天时评估疼痛、肿胀和牙关紧闭。使用 Friedman、Wilcoxon、Mann-Whitney 检验和效应大小评估数据。
共纳入 8 名男性和 12 名女性，平均年龄为 20.9 岁。初始疼痛均值为 7.94（±12.81）（第 1 组）和 5.50（±9.12）（第 2 组）（p>0.05）。组内分析显示疼痛、肿胀和牙关紧闭均有显著减轻（p<0.05）。组间比较肿胀和牙关紧闭无统计学差异（p>0.05）。效应大小范围从小（0.23）到大（1.29）。
臭氧水作为冲洗方法是可行的，与双蒸水相比不劣于后者，在第三磨牙手术切除后管理疼痛、肿胀和牙关紧闭方面具有令人满意的效果。
本临床试验于 2018 年 4 月 18 日在 ClinicalTrials.gov 注册，编号为 NCT03501225。
