Ozenne G, Morel A, Menard J F, Thauvin C, Samain J P, Lemeland J F
Laboratoire de Bactériologie, Chu de Rouen, France.
Am Rev Respir Dis. 1988 Oct;138(4):878-81. doi: 10.1164/ajrccm/138.4.878.
The drug susceptibility of two untypable strains of Mycobacterium avium complex were studied in 7H10 agar plates containing ethambutol (EMB), isoniazid (INH), rifampicin (RMP), ethionamide (ETH), and streptomycin (SM) alone and in two-drug combinations. The effective dose inhibiting 75% of the mycobacterial population (ED 75) was estimated by a regression analysis on the probit transformed inhibition percentages and plotted on an isobologram for each combination. No major discrepancies were found between strains. Five combinations (RMP plus INH, RMP plus EMB, EMB plus SM, INH plus EMB, and ETH plus INH) showed synergistic effect, whereas five other combinations (ETH plus EMB, ETH plus RMP, ETH plus SM, SM plus RMP, and SM plus INH) showed antagonistic effect. These in vitro results are not in combination with the known results of treatment of the M. avium diseases. We conclude that the effect of drug combinations against M. avium may be strain dependent and that it is important to determine this effect in vitro before setting up a treatment protocol.
在含有乙胺丁醇（EMB）、异烟肼（INH）、利福平（RMP）、乙硫异烟胺（ETH）和链霉素（SM）的7H10琼脂平板上，单独以及以两种药物组合的形式研究了两株不可分型鸟分枝杆菌复合群菌株的药敏性。通过对概率转换后的抑制百分比进行回归分析，估算出抑制75%分枝杆菌群体的有效剂量（ED75），并针对每种组合绘制在等效线图上。两株菌株之间未发现重大差异。五种组合（RMP加INH、RMP加EMB、EMB加SM、INH加EMB以及ETH加INH）显示出协同作用，而其他五种组合（ETH加EMB、ETH加RMP、ETH加SM、SM加RMP以及SM加INH）显示出拮抗作用。这些体外结果与已知的鸟分枝杆菌病治疗结果不一致。我们得出结论，药物组合对鸟分枝杆菌的作用可能取决于菌株，并且在制定治疗方案之前在体外确定这种作用很重要。
