硫醇/二硫键稳态在受精治疗中是否会影响第二次减数分裂中期卵母细胞的数量？
Does thiol/disulfide homeostasis affect the number of metaphase 2 oocyte in the treatment of fertilization?
作者信息
Ozdemir Ayse Z, Karlı Pervin, Neşeli Oğlu Salim
机构信息
Ondokuz Mayıs University IVF Center, Ondokuz Mayıs University Hospital, Samsun, Turkey.
Amasya University, Department of Obstetrics & Gynecology, Amasya, Turkey.
出版信息
Future Sci OA. 2020 Jan 14;6(2):FSO452. doi: 10.2144/fsoa-2019-0132.
AIM
To investigate the effect of thiol/disulfide homeostasis on the number of oocytes retrieved and metaphase 2 (M2) oocytes in patients undergoing fertilization.
METHOD
A prospective study of 94 patients who were admitted to the fertilization clinic was conducted. Serum samples were taken on the oocyte pick-up day and kept until the analysis. Thiol and disulfide were measured in order to evaluate the total thiol/disulfide.
RESULTS
A statistically significant correlation was observed between disulfide and M2.
CONCLUSION
This study provides an inexpensive and noninvasive method to measure oxidative stress, and suggests that there is a positive correlation between the number of M2 and disulfide, resulting in low-impact oxidative stress.
目的
探讨硫醇/二硫键稳态对接受体外受精患者的获卵数及中期Ⅱ（MⅡ）卵母细胞数量的影响。
方法
对94例入住体外受精诊所的患者进行前瞻性研究。在取卵日采集血清样本并保存至分析时。检测硫醇和二硫键以评估总硫醇/二硫键水平。
结果
观察到二硫键与MⅡ之间存在统计学显著相关性。
结论
本研究提供了一种廉价且无创的测量氧化应激的方法，并表明MⅡ数量与二硫键之间存在正相关，导致氧化应激影响较小。
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