Does thiol/disulfide homeostasis affect the number of metaphase 2 oocyte in the treatment of fertilization?
作者信息
Ozdemir Ayse Z, Karlı Pervin, Neşeli Oğlu Salim
机构信息
Ondokuz Mayıs University IVF Center, Ondokuz Mayıs University Hospital, Samsun, Turkey.
Amasya University, Department of Obstetrics & Gynecology, Amasya, Turkey.
出版信息
Future Sci OA. 2020 Jan 14;6(2):FSO452. doi: 10.2144/fsoa-2019-0132.
AIM
To investigate the effect of thiol/disulfide homeostasis on the number of oocytes retrieved and metaphase 2 (M2) oocytes in patients undergoing fertilization.
METHOD
A prospective study of 94 patients who were admitted to the fertilization clinic was conducted. Serum samples were taken on the oocyte pick-up day and kept until the analysis. Thiol and disulfide were measured in order to evaluate the total thiol/disulfide.
RESULTS
A statistically significant correlation was observed between disulfide and M2.
CONCLUSION
This study provides an inexpensive and noninvasive method to measure oxidative stress, and suggests that there is a positive correlation between the number of M2 and disulfide, resulting in low-impact oxidative stress.
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