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Noninvasive Testing Using Magnetic Resonance Imaging Techniques as Outcomes in Nonalcoholic Steatohepatitis Clinical Trials: How Full Is the Glass?

作者信息

Noureddin Nabil, Schattenberg Jörn M, Alkhouri Naim, Noureddin Mazen

机构信息

Department of Medicine University of Nevada Las Vegas School of Medicine Las Vegas NV.

Department of Medicine University Medical Centre Johannes Gutenberg University Mainz Germany.

出版信息

Hepatol Commun. 2020 Feb 3;4(2):141-144. doi: 10.1002/hep4.1473. eCollection 2020 Feb.

DOI:10.1002/hep4.1473
PMID:32025600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6996378/
Abstract
摘要

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Hepatol Commun. 2019 Nov 5;4(2):185-192. doi: 10.1002/hep4.1446. eCollection 2020 Feb.
2
Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.Resmetirom（MGL-3196）治疗非酒精性脂肪性肝炎：一项多中心、随机、双盲、安慰剂对照的 2 期临床试验。
Lancet. 2019 Nov 30;394(10213):2012-2024. doi: 10.1016/S0140-6736(19)32517-6. Epub 2019 Nov 11.
3
Change in hepatic fat content measured by MRI does not predict treatment-induced histological improvement of steatohepatitis.MRI 测量的肝内脂肪含量变化不能预测治疗引起的脂肪性肝炎组织学改善。
J Hepatol. 2020 Mar;72(3):401-410. doi: 10.1016/j.jhep.2019.09.018. Epub 2019 Oct 4.
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Past, present and future perspectives in nonalcoholic fatty liver disease.非酒精性脂肪性肝病的过去、现在和未来展望。
Nat Rev Gastroenterol Hepatol. 2019 Jun;16(6):377-386. doi: 10.1038/s41575-019-0144-8.
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Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis.非酒精性脂肪性肝病、非酒精性脂肪性肝炎及相关纤维化的诊断方法。
Hepatology. 2018 Jul;68(1):349-360. doi: 10.1002/hep.29721.
10
Serum biomarkers can predict a change in liver fibrosis 1 year after lifestyle intervention for biopsy-proven NASH.血清生物标志物可预测经活检证实的 NASH 生活方式干预 1 年后肝纤维化的变化。
Liver Int. 2017 Dec;37(12):1887-1896. doi: 10.1111/liv.13480. Epub 2017 Jun 14.