Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
Int Arch Occup Environ Health. 2020 Jul;93(5):659-668. doi: 10.1007/s00420-020-01524-7. Epub 2020 Feb 5.
To examine associations with occupational livestock or other animal dust exposure and offspring cancer risk.
In this population-based case-control study of Danish children aged < 17 years old, 5078 childhood cancer cases diagnosed 1968-2016 were matched to cancer-free controls by birth year and sex (n = 123,228). Occupational livestock or animal dust exposure was identified using a job-exposure matrix. We employed multivariable conditional logistic regression models to estimate associations with offspring cancer for births 1968-2016 and 1989-2016, with the latter timeframe reflecting a period of presumed higher exposure due to changes in Danish farming practices. Sensitivity analyses considered place of birth (urban areas vs. rural areas and small towns).
For births 1968-2016, paternal exposure from offspring birth to cancer diagnosis was associated with central nervous system tumors (adjusted odds ratio [OR] = 1.30, 95% confidence interval [CI] 1.04-1.63) and germ cell tumors (OR = 1.82, 95% CI 1.05-3.27), while maternal pregnancy exposure was associated with astrocytoma (OR = 1.89, 95% CI 1.00-3.57). For births 1989-2016, paternal exposure from offspring birth to cancer diagnosis was negatively associated with acute lymphoid leukemia (OR = 0.58, 95% CI 0.33-1.00). For births in rural areas only, maternal exposure from offspring birth to cancer diagnosis was positively associated with acute myeloid leukemia (OR = 2.16, 95% CI 1.09-4.29).
This study suggests that paternal occupational animal exposure is associated with offspring germ cell tumors, and maternal pregnancy exposure with astrocytomas. Our results are mixed with respect to leukemia subtypes.
探讨职业性牲畜或其他动物粉尘接触与子女癌症风险的关联。
在这项基于人群的丹麦儿童病例对照研究中，纳入了 1968 年至 2016 年诊断为<17 岁的 5078 例儿童癌症病例，并按出生年份和性别与无癌症对照组（n=123228）相匹配。职业性牲畜或动物粉尘接触情况通过职业暴露矩阵进行识别。我们采用多变量条件逻辑回归模型，以评估 1968 年至 2016 年和 1989 年至 2016 年出生的子女癌症与职业性牲畜或动物粉尘接触的关联，后者的时间范围反映了由于丹麦农业实践的变化，假定接触水平更高的时期。敏感性分析考虑了出生地（城市地区与农村地区和小镇）。
对于 1968 年至 2016 年出生的子女，从子女出生到癌症诊断的父亲职业暴露与中枢神经系统肿瘤（调整后的比值比 [OR] = 1.30，95%置信区间 [CI] = 1.04-1.63）和生殖细胞瘤（OR = 1.82，95% CI = 1.05-3.27）相关，而母亲妊娠期间的职业暴露与星形细胞瘤（OR = 1.89，95% CI = 1.00-3.57）相关。对于 1989 年至 2016 年出生的子女，从子女出生到癌症诊断的父亲职业暴露与急性淋巴细胞白血病（OR = 0.58，95% CI = 0.33-1.00）呈负相关。仅在农村地区出生的子女中，母亲从子女出生到癌症诊断的职业暴露与急性髓细胞白血病（OR = 2.16，95% CI = 1.09-4.29）呈正相关。
这项研究表明，父亲的职业性动物暴露与子女生殖细胞瘤有关，而母亲妊娠期间的暴露与星形细胞瘤有关。我们的结果在白血病亚型方面存在差异。
