产前暴露于空气毒物与儿童期恶性生殖细胞肿瘤。
Prenatal Exposure to Air Toxics and Malignant Germ Cell Tumors in Young Children.
机构信息
Department of Epidemiology, University of California, Los Angeles Fielding School of Public Health, Los Angeles, California (Dr Hall, Dr von Ehrenstein, Dr Ritz, Dr Heck); Department of Environmental Health Sciences, University of California, Los Angeles Fielding School of Public Health, Los Angeles, California (Dr Ritz); Department of Community Health Sciences, University of California, Los Angeles, Fielding School of Public Health, Los Angeles, California (Dr von Ehrenstein); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California (Dr Cockburn); Spatial Sciences Institute, Dornsife College of Arts, Letters and Sciences, University of Southern California, Los Angeles, California (Dr Escobedo); Leidos, Inc., San Diego, California (Dr Hall).
出版信息
J Occup Environ Med. 2019 Jun;61(6):529-534. doi: 10.1097/JOM.0000000000001609.
OBJECTIVE
To assess prenatal air toxics exposure and risk for childhood germ cell tumors (GCTs) by histological subtype (yolk sac tumor and teratoma).
METHODS
In this case-control study, GCT cases less than 6 years (n = 243) identified from California Cancer Registry records were matched by birth year to cancer-free population controls (n = 147,100), 1984 to 2013. Routinely monitored air toxic exposures were linked to subjects' birth address. Logistic regression estimated GCT risks per interquartile range increase in exposure.
RESULTS
Prenatal exposure to various highly-correlated, traffic-related air toxics during the second trimester increased GCT risk, particularly 1,3-butadiene (odds ratio [OR] = 1.51; 95% confidence interval [CI] = 1.01, 2.26) and meta/para-xylene (OR = 1.56; 95% CI = 1.10, 2.21). Analyses by subtype indicated elevated ORs for yolk sac tumors but not teratomas.
CONCLUSION
Our estimated ORs are consistent with positive associations between some prenatal traffic-related air toxics and GCT risk, notably yolk sac tumors.
目的
通过组织学亚型（卵黄囊瘤和畸胎瘤）评估产前空气毒物暴露与儿童生殖细胞肿瘤（GCT）的风险。
方法
在这项病例对照研究中，从加利福尼亚癌症登记处记录中确定的小于 6 岁的 GCT 病例（n=243），按照出生年份与无癌症人群对照（n=147100）进行匹配，时间范围为 1984 年至 2013 年。对常规监测的空气毒物暴露与受试者的出生地址进行关联。使用逻辑回归估计每增加一个四分位间距的暴露水平与 GCT 风险之间的关系。
结果
在妊娠中期，接触到各种高度相关的交通相关空气毒物会增加 GCT 的风险，特别是 1,3-丁二烯（OR=1.51；95%置信区间 [CI] = 1.01, 2.26）和间/对二甲苯（OR=1.56；95%CI=1.10, 2.21）。按亚型进行分析表明，卵黄囊瘤的比值比（OR）升高，但畸胎瘤则不然。
结论
我们的估计比值比与一些产前交通相关空气毒物与 GCT 风险之间的正相关关系一致，特别是卵黄囊瘤。
Zotero 插件