Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo; Rua Pedro de Toledo 669, Vila Clementino, São Paulo - SP 04039-032, Brazil.
Curr Protein Pept Sci. 2020;21(12):1223-1228. doi: 10.2174/1389203721666200206161912.
Parkinson´s disease (PD) and depression have an interplay at multiple cellular levels, a phenomenon which is translated into clinical data showing that depressive patients presented an enhanced risk for developing PD. The pathogenesis of both diseases is under intensive debate as correlated to dysregulations related to Ca2+ signaling.
Then, revealing this interplay between these diseases may provide novel insights into the pathogenesis of them.
Publications involving Ca2+ signaling, PD and depression (alone or combined) were collected by searching PubMed and EMBASE.
Not surprisingly, calcium (Ca2+) channel blockers (CCBs), classical antihypertensive medicines, have been demonstrated off-label effects, such as alleviating both PD and depression symptoms.
A mechanism under debate for the antiparkinsonism and antidepressant effects associated to CCBs is focused on the restoration of Ca2+ signaling dysregulations. In addition, previous studies have observed that CCBs can affect Ca2+/cAMP signaling.
Thus, this article discussed the role of Ca2+/cAMP signaling in the interplay between depression and PD, including the implications for the pharmacotherapy involving CCBs.
帕金森病（PD）和抑郁症在多个细胞水平上相互作用，这一现象转化为临床数据表明，抑郁患者患 PD 的风险增加。这两种疾病的发病机制与 Ca2+信号相关的失调密切相关，目前仍在激烈争论中。
揭示这两种疾病之间的相互作用可能为它们的发病机制提供新的见解。
通过搜索 PubMed 和 EMBASE 收集涉及 Ca2+信号、PD 和抑郁症（单独或联合）的出版物。
不出所料，钙（Ca2+）通道阻滞剂（CCB），经典的降压药物，已被证明具有缓解 PD 和抑郁症状的标签外作用。
CCB 与抗帕金森病和抗抑郁作用相关的一个有争议的机制集中在恢复 Ca2+信号失调上。此外，先前的研究观察到 CCBs 可以影响 Ca2+/cAMP 信号。
因此，本文讨论了 Ca2+/cAMP 信号在抑郁症和 PD 之间相互作用中的作用，包括涉及 CCB 的药物治疗的影响。
