Bergantin Leandro B
Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rua Pedro de Toledo, 669 - Vila Clementino, Sao Paulo - SP, Brazil.
Curr Diabetes Rev. 2020;16(3):238-241. doi: 10.2174/1573399815666190711113644.
A link between diabetes and Parkinson´s disease (PD) has been established by several reports. Consistent data report that people diagnosed with diabetes have demonstrated an enhanced risk of manifesting PD in their lifetime. The working principles involved in this link have been extensively discussed. Over the last decade, diabetes has been reported to be correlated with an increased risk of dementia, suggesting a potential role of diabetes, or insulin signalling dysregulations, in neurodegeneration. In addition, it is nowadays highly debated that dysregulations related to Ca2+ signalling may be an upstream issue which could also link diabetes and PD. Ca2+ and cAMP signalling pathways (Ca2+/cAMP signalling) control both the neurotransmitters/hormones release and neuronal death.
Considering our previous reports about Ca2+/cAMP signalling, the putative contribution of Ca2+/cAMP signalling in this link (between diabetes and PD) is discussed in this paper.
多项报告已证实糖尿病与帕金森病（PD）之间存在联系。一致的数据表明，被诊断患有糖尿病的人一生中患帕金森病的风险有所增加。关于这种联系所涉及的工作原理已进行了广泛讨论。在过去十年中，据报道糖尿病与痴呆症风险增加相关，这表明糖尿病或胰岛素信号失调在神经退行性变中可能发挥潜在作用。此外，如今关于与Ca2+信号相关的失调可能是一个上游问题，这也可能将糖尿病和帕金森病联系起来的讨论非常激烈。Ca2+和cAMP信号通路（Ca2+/cAMP信号）控制神经递质/激素释放和神经元死亡。
考虑到我们之前关于Ca2+/cAMP信号的报告，本文讨论了Ca2+/cAMP信号在这种联系（糖尿病与帕金森病之间）中的假定作用。
