Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 669 - Vila Clementino, Sao Paulo, Brazil.
Curr Pharm Des. 2020;26(27):3326-3331. doi: 10.2174/1381612826666200318144521.
Considering a consistent body of evidence has been showing that schizophrenia patients have had an increased risk of developing dementia. The hypothesis that dementia and schizophrenia share a complex link, is emerging. It is highly discussed that dysregulations related to Ca2+ signalling, e.g., an increase of the intracellular concentration of Ca2+, could link both diseases, in addition to cAMP signalling pathways.
Thus, revealing this interplay between schizophrenia and dementia may provide novel insights into the pathogenesis of these diseases.
Publications involving Ca2+ and cAMP signalling pathways, dementia and schizophrenia (alone or combined) were collected by searching PubMed and EMBASE.
Both Ca2+ and cAMP signalling pathways (Ca2+/cAMP signalling) control the release of neurotransmitters/ hormones and neuronal death, and dysregulations of these cellular processes may be involved in both diseases.
Bearing in mind the experience of our group in this field, this article debated the involvement of Ca2+/cAMP signalling in this link between schizophrenia and dementia, including its pharmacological implications.
有一致的证据表明精神分裂症患者痴呆的风险增加。痴呆症和精神分裂症之间存在复杂联系的假设正在出现。人们高度讨论了与 Ca2+信号相关的失调，例如细胞内 Ca2+浓度的增加，除了 cAMP 信号通路外，还可能将这两种疾病联系起来。
因此，揭示精神分裂症和痴呆症之间的这种相互作用可能为这些疾病的发病机制提供新的见解。
通过搜索 PubMed 和 EMBASE 收集涉及 Ca2+和 cAMP 信号通路、痴呆症和精神分裂症（单独或联合）的出版物。
Ca2+和 cAMP 信号通路（Ca2+/cAMP 信号）控制神经递质/激素的释放和神经元死亡，这些细胞过程的失调可能与这两种疾病都有关。
考虑到我们小组在该领域的经验，本文讨论了 Ca2+/cAMP 信号在精神分裂症和痴呆症之间的这种联系中的作用，包括其药理学意义。
