Department of Neurorehabilitation, IRCCS Don Carlo Gnocchi, Milan, Italy.
Department of Movement, Human and Health Sciences, Division of Health Sciences, University of Rome Foro Italico, Rome, Italy.
Physiotherapy. 2020 Mar;106:36-42. doi: 10.1016/j.physio.2019.12.007. Epub 2019 Dec 23.
To compare a 6-week virtual reality (VR) rehabilitation programme with a conventional rehabilitation programme in patients with Parkinson's disease.
Prospective, single-blinded, randomised controlled trial.
Outpatients.
Fifty-one patients with Parkinson's disease were assigned at random to a VR rehabilitation programme or a conventional rehabilitation programme.
Both programmes ran for 6 consecutive weeks, with a 40-minute session three times per week.
The Balance Berg Scale (BBS) was used to measure balance. Secondary outcome measures were: Dynamic Gait Index (DGI) to evaluate ability to adapt gait to complex walking tasks; Disabilities of the Arm, Shoulder and Hand (DASH) scale to measure performance of the upper limb; and Short Form 36 (SF-36) to evaluate quality of life.
The VR rehabilitation programme led to an increase in BBS score {45.6 [standard deviation (SD) 7.9] vs 49.2 (SD 8.1), mean difference 3.6, 95% confidence interval (CI) 1.3 to 5.9; P=0.003}, DGI score [18.7 (SD 4.7) vs 20.2 (SD 4.2), mean difference 1.6, 95% CI 0.6 to 2.5; P=0.003] and SF-36 mental composite score [37.7 (SD 11.4) vs 43.5 (SD 9.2), mean difference 5.8, 95% CI 0.4 to 11.3; P=0.037], and a decrease in DASH scale score [29.6 (SD 17.5) vs 21.6 (SD 15.1), mean difference -7.9, 95% CI -13.7 to -2.2; P=0.009]. In contrast, the conventional rehabilitation programme only led to a decrease in DASH scale score [30.3 (SD 18.1) vs 25.1 (SD 15.8), mean difference -5.2, 95% CI -8.8 to -1.5; P=0.007].
These findings suggest that rehabilitation is useful in Parkinson's disease, and the VR rehabilitation programme was more effective in determining overall improvement than the conventional rehabilitation programme.
NCT02807740.
比较虚拟现实（VR）康复计划与帕金森病患者的常规康复计划。
前瞻性、单盲、随机对照试验。
门诊。
51 名帕金森病患者被随机分配到 VR 康复计划或常规康复计划组。
两组均连续进行 6 周，每周 3 次，每次 40 分钟。
平衡伯格量表（BBS）用于评估平衡能力。次要观察指标：动态步态指数（DGI）评估适应复杂步行任务的步态能力；手臂、肩部和手部残疾量表（DASH）评估上肢运动功能；短表 36 项（SF-36）评估生活质量。
VR 康复计划可使 BBS 评分增加{45.6[标准差（SD）7.9]比 49.2（SD 8.1），平均差异 3.6，95%置信区间（CI）1.3 至 5.9；P=0.003}，DGI 评分[18.7（SD 4.7）比 20.2（SD 4.2），平均差异 1.6，95%CI 0.6 至 2.5；P=0.003]和 SF-36 精神综合评分[37.7（SD 11.4）比 43.5（SD 9.2），平均差异 5.8，95%CI 0.4 至 11.3；P=0.037]，以及 DASH 量表评分降低[29.6（SD 17.5）比 21.6（SD 15.1），平均差异-7.9，95%CI-13.7 至-2.2；P=0.009]。相比之下，常规康复计划仅使 DASH 量表评分降低[30.3（SD 18.1）比 25.1（SD 15.8），平均差异-5.2，95%CI-8.8 至-1.5；P=0.007]。
这些发现表明康复对帕金森病有益，与常规康复计划相比，VR 康复计划在确定整体改善方面更有效。
NCT02807740。
