University Institute of Physical Therapy, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan,
Riphah College of Rehabilitation and Allied Health Sciences Riphah International University, Faisalabad Campus, Faisalabad, Pakistan,
Neurodegener Dis. 2020;20(2-3):90-96. doi: 10.1159/000511916. Epub 2020 Dec 17.
Parkinson's disease (PD) is one of the most common neurological disorders, of insidious onset, with major motor symptomatology including bradykinesia, rest tremor, rigidity, and postural disturbances. Virtual reality (VR) and motor imagery (MI) are among the more innovative techniques for the rehabilitation of patients with PD which promote motor learning both through explicit and implicit processes. This study is unique in that it will examine the combined effects of VR and MI on motor function, balance and activities of daily living (ADLs) in patients with PD.
The aim of this work is to investigate the effects of VR with MI techniques in addition to routine physical therapy on motor function, balance, and ADLs in patients with PD.
This is a two-armed parallel design, single-blinded (assessor blinded), single-centered, randomized controlled trial, and the study protocol is based on SPIRIT guidelines. Thirty-four patients with PD (Modified Hoehn and Yahr stages I-III) will be randomly allocated with a 1:1 ratio into Group A (control group) and Group B (treatment group). Group A will be given routine physical therapy in 40-min sessions and 20 min of walking and cycling with a short period of rest, every alternate day (3 days per week) for 12 weeks, while for Group B routine physical therapy protocols along with VR and MI will be used in 60-min sessions, every alternate day (3 days per week) for 12 weeks. The primary outcome measures are as follows: (i) the Unified PD Rating Scale (UPDRS; part III), (ii) the Berg Balance Scale (BBS), and the Activities-Specific Balance Confidence Scale (ABC). The secondary outcome measure is the UPDRS (part II). Assessments will be recorded at baseline, the sixth and twelfth weeks of therapy, and 1 month after the discontinuation of therapy. Clinical Study Registration: This randomized controlled prospective study was registered with the Iranian Registry of clinical trials (IRCT20200221046567N1) on April 1, 2020 (https://www.irct.ir/trial/46073).
帕金森病（PD）是最常见的神经退行性疾病之一，起病隐匿，主要运动症状包括运动迟缓、静止性震颤、僵硬和姿势不稳。虚拟现实（VR）和运动想象（MI）是 PD 患者康复的创新技术之一，通过外显和内隐过程促进运动学习。本研究的独特之处在于，它将研究 VR 和 MI 技术联合应用对 PD 患者运动功能、平衡和日常生活活动（ADL）的综合影响。
本研究旨在探讨 VR 联合 MI 技术在常规物理治疗基础上对 PD 患者运动功能、平衡和 ADL 的影响。
这是一项双臂平行设计、单盲（评估者盲法）、单中心、随机对照试验，研究方案基于 SPIRIT 指南。将 34 例 PD 患者（改良 Hoehn 和 Yahr 分期 I-III 期）随机分为 A 组（对照组）和 B 组（治疗组），每组 17 例。A 组给予常规物理治疗，每次 40 分钟，20 分钟步行和骑自行车，休息短时间，隔天一次（每周 3 天），共 12 周；B 组在常规物理治疗方案的基础上，每次 60 分钟，隔天一次（每周 3 天），共 12 周。主要观察指标如下：（i）统一帕金森病评定量表（UPDRS；第 III 部分），（ii）伯格平衡量表（BBS）和活动特异性平衡信心量表（ABC）。次要观察指标是 UPDRS（第 II 部分）。在基线、治疗第 6 周和第 12 周以及治疗停止后 1 个月进行评估。
这项随机对照前瞻性研究于 2020 年 4 月 1 日在伊朗临床试验注册中心（IRCT20200221046567N1）注册（https://www.irct.ir/trial/46073）。
