Department of Endocrinology and Metabolism, Bursa Yuksek Ihtisas Education and Training Hospital, University of Health Sciences, Bursa, Turkey.
Department of Internal Medicine, Bursa Yuksek Ihtisas Education and Training Hospital, University of Health Sciences, Bursa, Turkey.
Metab Syndr Relat Disord. 2020 Apr;18(3):161-167. doi: 10.1089/met.2019.0108. Epub 2020 Feb 6.
To investigate the association of food addiction (FA) with the psychosocial functioning and metabolic parameters in obese patients seeking weight-loss treatment. Two hundred twenty-four obese patients (male/female: 28/196) with a mean age of 44.5 ± 13.4 years and body mass index (BMI) of 41.6 ± 7.2 were included in the study. After receiving sociodemographic data and medical history, detailed physical examination, including anthropometric measurements, was performed by an experienced physician. Blood samples were taken after 8-12 hr of fasting. The presence of FA was evaluated by using Yale Food Addiction Scale (YFAS). Psychological evaluation was performed by using a self-reported Patient Health Questionnaire-9 (PHQ-9) and health-related quality of life using the 36-item short-form health survey (SF-36). Seventy-two of 224 (32.1%) patients met the criteria for FA, according to YFAS. The mean age of patients with FA was younger compared with patients without FA ( < 0.001). There was no statistically significant difference between the patients with and without FA in terms of BMI, fat percentage, and waist circumference ( = 0.440, = 0.644, and = 0.144, respectively). The depression frequency was significantly higher (61.1%, < 0.001), while the SF-36 score of mental health was lower ( = 0.027) in patients with FA than in the patients without FA. Age- and sex-adjusted mean fasting plasma glucose level was lower in patients with FA ( = 0.021), but serum insulin levels, HOMA-IR (homeostasis model assessment of insulin resistance), HbA1c (hemoglobin A1c), lipid parameters, and vascular adiposity index were comparable. We found that FA frequency was very high in obese patients seeking treatment for weight loss, and it correlates with psychosocial functioning more than metabolic parameters.
为了探究食物成瘾（FA）与肥胖患者寻求减肥治疗时的心理社会功能和代谢参数之间的关联。研究纳入了 224 名肥胖患者（男/女：28/196），平均年龄为 44.5±13.4 岁，体重指数（BMI）为 41.6±7.2。在接受社会人口统计学数据和病史后，由一位经验丰富的医生进行详细的体格检查，包括人体测量学测量。在禁食 8-12 小时后抽取血液样本。通过耶鲁食物成瘾量表（YFAS）评估 FA 的存在。通过患者健康问卷-9（PHQ-9）进行心理评估，并使用 36 项简短健康调查（SF-36）评估健康相关的生活质量。根据 YFAS，224 名患者中有 72 名（32.1%）符合 FA 标准。有 FA 的患者的平均年龄明显小于无 FA 的患者（ < 0.001）。有 FA 和无 FA 的患者在 BMI、体脂百分比和腰围方面无统计学差异（ = 0.440、 = 0.644 和 = 0.144）。有 FA 的患者的抑郁频率明显更高（61.1%， < 0.001），而 FA 患者的心理健康 SF-36 评分较低（ = 0.027）。校正年龄和性别后，FA 患者的空腹血浆葡萄糖水平较低（ = 0.021），但血清胰岛素水平、HOMA-IR（胰岛素抵抗的稳态模型评估）、HbA1c（糖化血红蛋白）、血脂参数和血管脂肪指数无差异。我们发现，寻求减肥治疗的肥胖患者中 FA 的发生率非常高，它与心理社会功能的相关性大于代谢参数。
