Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802.
Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802; Neuroscience Curriculum, Pennsylvania State University, University Park, PA 16802.
Neuroscience. 2019 Nov 1;419:1-4. doi: 10.1016/j.neuroscience.2019.08.014. Epub 2019 Sep 2.
Somatostatin is a neuropeptide thought to play a role in a variety of neuropsychiatric disorders, and is important for healthy aging and behavioral resiliency. Physiological conditions underlying somatostatin peptidergic release are not well-defined. Using a combination of optogenetic and biochemical approaches in transgenic mice, we demonstrate an assay for the induction and inhibition of somatostatin release in mouse acute brain slices.
生长抑素是一种神经肽，被认为在多种神经精神疾病中发挥作用，对健康衰老和行为弹性很重要。生长抑素肽释放的生理条件尚未明确。本研究使用转基因小鼠的光遗传学和生化方法的组合，展示了一种用于检测小鼠急性脑片中生长抑素释放的诱导和抑制的测定法。
