用于潜在治疗阿尔茨海默病及其他中枢神经系统疾病的生长抑素受体亚型4激动剂
Somatostatin Receptor Subtype 4 Agonists for Potential Treatment of Alzheimer's Disease and Other Central Nervous System Disorders.
作者信息
Abdel-Magid Ahmed F
机构信息
PI Health Sciences, 100 Jade Park, Chelsea, Alabama 35043, United States.
出版信息
ACS Med Chem Lett. 2024 May 6;15(6):766-768. doi: 10.1021/acsmedchemlett.4c00185. eCollection 2024 Jun 13.
Abstract
The invention in this patent application relates to -(pyrrolidine-3-yl or piperidin-4-yl)acetamide derivatives represented generally by formula 1. These compounds possess activities as somatostatin receptor 4 (SSTR4) agonists and may potentially be beneficial in the treatment of diseases or disorders, associated with SSTR4 such as Alzheimer's disease (AD) and other CNS disorders such as epilepsy and depression.
摘要
本专利申请中的发明涉及通式1一般表示的-(吡咯烷-3-基或哌啶-4-基)乙酰胺衍生物。这些化合物具有作为生长抑素受体4 (SSTR4)激动剂的活性，并且可能对治疗与SSTR4相关的疾病或病症有益，例如阿尔茨海默病(AD)以及其他中枢神经系统病症，如癫痫和抑郁症。
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