Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Department of Gynecology and Obstetrics, University Medical Center Ulm, Ulm, Germany.
Sci Rep. 2020 Feb 6;10(1):1996. doi: 10.1038/s41598-020-58808-8.
Psychosocial stress is thought to influence gestational weight gain (GWG), but results are inconsistent. We investigated the relationship of questionnaire-based maternal stress and related constructs assessed at childbirth with maternal weight measured throughout pregnancy. Data were derived from the Ulm SPATZ Health Study, a birth cohort recruited from the general population (04/2012-05/2013, Ulm, Germany). Adjusted generalized estimating equations were performed. Regression coefficients (b) and 95% confidence intervals, each highest versus lowest tertile of stress or related constructs, are presented. In 748 women, we observed positive associations for maternal chronic stress (b = 4.36 kg (1.77; 6.95)), depressive symptoms (b = 2.50 kg (0.14; 4.86)), anxiety symptoms (b = 3.26 kg (0.62, 5.89)), and hair cortisol (b = 3.35 kg (0.86; 5.83)) with maternal weight at the first gestational month. GWG was considerably lower in mothers with higher chronic stress. Pregnancy-related anxiety was positively related to weight at first month (b = 4.16 kg (1.74; 6.58)) and overall GWG. In contrast, no association was observed between anxiety symptoms and GWG. Odds ratios for association with inadequate weight gain according to Institute of Medicine recommended cutoffs differed from the results presented obove. There is evidence of an association between stress and weight gain lying beyond the recommended cut-offs, which however needs further corroboration.
心理社会压力被认为会影响妊娠体重增加（GWG），但结果不一致。我们研究了分娩时基于问卷的产妇压力和相关结构与整个孕期测量的产妇体重之间的关系。数据来自于乌尔姆 SPATZ 健康研究，这是一个从普通人群中招募的出生队列（2012 年 4 月至 2013 年 5 月，德国乌尔姆）。进行了调整的广义估计方程。呈现了每个最高与最低三分位的压力或相关结构的回归系数（b）和 95%置信区间。在 748 名妇女中，我们观察到慢性产妇压力（b=4.36kg（1.77；6.95））、抑郁症状（b=2.50kg（0.14；4.86））、焦虑症状（b=3.26kg（0.62；5.89））和头发皮质醇（b=3.35kg（0.86；5.83））与第一个妊娠月的产妇体重呈正相关。有较高慢性压力的产妇 GWG 明显较低。与妊娠相关的焦虑与第一个月的体重（b=4.16kg（1.74；6.58））和整个 GWG 呈正相关。相比之下，焦虑症状与 GWG 之间没有关联。根据医学研究所推荐的切点，与体重不足增加相关的比值比与上述结果不同。有证据表明，压力与体重增加之间存在关联，超出了推荐的切点，但这需要进一步证实。
