肽YY，2型糖尿病的一种治疗选择？
PYY, a Therapeutic Option for Type 2 Diabetes?
作者信息
Guida Claudia, Ramracheya Reshma
机构信息
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
出版信息
Clin Med Insights Endocrinol Diabetes. 2020 Jan 22;13:1179551419892985. doi: 10.1177/1179551419892985. eCollection 2020.
Abstract
Metabolic surgery leads to rapid and effective diabetes reversal in humans, by weight-independent mechanisms. The crucial improvement in pancreatic islet function observed after surgery is induced by alteration in several factors, including gut hormones. In addition to glucagon-like peptide 1 (GLP-1), increasing lines of evidence show that peptide tyrosine tyrosine (PYY) plays a key role in the metabolic benefits associated with the surgery, ranging from appetite regulation to amelioration of islet secretory properties and survival. Here, we summarize the current knowledge and the latest advancements in the field, which pitch a strong case for the development of novel PYY-based therapy for the treatment of diabetes.
摘要
代谢手术通过与体重无关的机制，能快速有效地逆转人类糖尿病。手术后观察到的胰岛功能的关键改善是由多种因素的改变引起的，包括肠道激素。除了胰高血糖素样肽1（GLP-1）外，越来越多的证据表明，酪酪肽（PYY）在与手术相关的代谢益处中起关键作用，从食欲调节到改善胰岛分泌特性和存活。在此，我们总结了该领域的现有知识和最新进展，这些都有力地支持了开发基于PYY的新型糖尿病治疗方法。
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