Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Maurice Wilkins Centre for Biodiscovery, Auckland, New Zealand.
Adv Exp Med Biol. 2020;1226:1-22. doi: 10.1007/978-3-030-36214-0_1.
The tumour microenvironment (TME) of intestinal tumours is highly complex and comprises a network of stromal cells, tumour cells, immune cells and fibroblasts, as well as microorganisms. The tumour location, environmental factors and the tumour cells themselves influence the cells within the TME. Immune cells can destroy tumour cells and are associated with better patient prognosis and response to therapy; however, immune cells are highly plastic and easily influenced to instead promote tumour growth. The interaction between local immune cells and the microbiome can lead to progression or regression of intestinal tumours. In this chapter, we will discuss how tumour development and progression can influence, and be influenced by, the microenvironment surrounding it, focusing on immune and fibroblastic cells, and the intestinal microbiota, particularly in the context of colorectal cancer.
肠道肿瘤的肿瘤微环境（TME）非常复杂，包含了基质细胞、肿瘤细胞、免疫细胞和成纤维细胞网络，以及微生物群。肿瘤位置、环境因素和肿瘤细胞本身都会影响 TME 中的细胞。免疫细胞可以破坏肿瘤细胞，并与更好的患者预后和对治疗的反应相关；然而，免疫细胞具有高度的可塑性，很容易受到影响转而促进肿瘤生长。局部免疫细胞和微生物组之间的相互作用可导致肠道肿瘤的进展或消退。在本章中，我们将讨论肿瘤的发展和进展如何影响其周围的微环境，以及如何受其影响，重点讨论免疫和成纤维细胞，以及肠道微生物群，特别是在结直肠癌的背景下。
