Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, Talca, Chile.
Adv Exp Med Biol. 2020;1226:23-35. doi: 10.1007/978-3-030-36214-0_2.
A compelling body of evidence has demonstrated that gastric cancer has a very particular tumor microenvironment, a signature very suitable to promote tumor progression and metastasis. Recent investigations have provided new insights into the multiple molecular mechanisms, defined by genetic and epigenetic mechanisms, supporting a very active cross talk between the components of the tumor microenvironment and thus defining the fate of tumor progression. In this review, we intend to highlight the role of very active contributors at gastric cancer TME, particularly cancer-associated fibroblasts, bone marrow-derived cells, tumor-associated macrophages, and tumor-infiltrating neutrophils, all of them surrounded by an overtime changing extracellular matrix. In addition, the very active cross talk between the components of the tumor microenvironment, defined by genetic and epigenetic mechanisms, thus defining the fate of tumor progression, is also reviewed.
大量证据表明，胃癌具有非常特殊的肿瘤微环境，这种特征非常适合促进肿瘤的进展和转移。最近的研究为多种分子机制提供了新的见解，这些机制由遗传和表观遗传机制定义，支持肿瘤微环境成分之间非常活跃的串扰，从而定义肿瘤进展的命运。在这篇综述中，我们旨在强调在胃癌 TME 中非常活跃的贡献者的作用，特别是癌相关成纤维细胞、骨髓来源细胞、肿瘤相关巨噬细胞和肿瘤浸润中性粒细胞，所有这些细胞都被一个不断变化的细胞外基质所包围。此外，还回顾了由遗传和表观遗传机制定义的肿瘤微环境成分之间非常活跃的串扰，从而定义了肿瘤进展的命运。
