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生物打印路线图。

The bioprinting roadmap.

机构信息

Department of Mechanical Engineering and Mechanics, College of Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, United States of America. Department of Mechanical Engineering, Tsinghua University, Beijing 100084, People's Republic of China.

出版信息

Biofabrication. 2020 Feb 6;12(2):022002. doi: 10.1088/1758-5090/ab5158.

Abstract

This bioprinting roadmap features salient advances in selected applications of the technique and highlights the status of current developments and challenges, as well as envisioned advances in science and technology, to address the challenges to the young and evolving technique. The topics covered in this roadmap encompass the broad spectrum of bioprinting; from cell expansion and novel bioink development to cell/stem cell printing, from organoid-based tissue organization to bioprinting of human-scale tissue structures, and from building cell/tissue/organ-on-a-chip to biomanufacturing of multicellular engineered living systems. The emerging application of printing-in-space and an overview of bioprinting technologies are also included in this roadmap. Due to the rapid pace of methodological advancements in bioprinting techniques and wide-ranging applications, the direction in which the field should advance is not immediately clear. This bioprinting roadmap addresses this unmet need by providing a comprehensive summary and recommendations useful to experienced researchers and newcomers to the field.

摘要

本生物打印路线图重点介绍了该技术在选定应用中的显著进展,突出了当前发展和挑战的现状,以及对科学和技术的预期进展,以应对年轻且不断发展的技术所面临的挑战。本路线图涵盖的主题广泛,包括生物打印的各个方面;从细胞扩增和新型生物墨水的开发,到细胞/干细胞打印,从基于类器官的组织构建,到人类规模组织结构的生物打印,以及从细胞/组织/器官芯片的构建到多细胞工程活体系统的生物制造。本路线图还包括在太空中打印的新兴应用以及生物打印技术的概述。由于生物打印技术的方法学进步和广泛应用的快速步伐,该领域应前进的方向尚不清楚。本生物打印路线图通过提供对有经验的研究人员和该领域新手有用的全面总结和建议,满足了这一未满足的需求。

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